Al-Yafeai, Z., A. Yurdagul, J. M. Peretik, M. Alfaidi, P. A. Murphy, and A. W. Orr. Endothelial FN (Fibronectin) deposition by α5β1 integrins drives atherogenic inflammation. Arterioscler. Thromb. Vasc. Biol. 38:2601–2614, 2018.
Al-Yahya, S., et al. Human Cytokinome Analysis for Interferon Response. J. Virol. 89:7108–7119, 2015.
Amaral, M. L., G. A. Erikson, and M. N. Shokhirev. BART: bioinformatics array research tool. BMC Bioinformatics. 19:1–6, 2018.
An, G., et al. Effects of CCL5 on the biological behavior of breast cancer and the mechanisms of its interaction with tumor-associated macrophages. Oncol. Rep. 42:2499–2511, 2019.
Argaw, A. T., et al. IL-1β regulates blood–brain barrier permeability via reactivation of the hypoxia-angiogenesis program. J. Immunol. 177:5574–5584, 2006.
Avraham, H. K., S. Jiang, Y. Fu, H. Nakshatri, H. Ovadia, and S. Avraham. Angiopoietin-2 mediates blood–brain barrier impairment and colonization of triple-negative breast cancer cells in brain. J. Pathol. 232:369–381, 2014.
Beard, R. S., et al. Non-muscle Mlck is required for ß-catenin- and FoxO1-dependent downregulation of Cldn5 in IL-1ß-mediated barrier dysfunction in brain endothelial cells. J. Cell Sci. 127:1840–1853, 2014.
Bersini, S., et al. A microfluidic 3D invitro model for specificity of breast cancer metastasis to bone. Biomaterials. 35:2454–2461, 2014.
Blamire, A. M., D. C. Anthony, B. Rajagopalan, N. R. Sibson, V. H. Perry, and P. Styles. Interleukin-1β-induced changes in blood–brain barrier permeability, apparent diffusion coefficient, and cerebral blood volume in the rat brain: A magnetic resonance study. J. Neurosci. 20:8153–8159, 2000.
Bos, P. D., et al. Genes that mediate breast cancer metastasis to the brain. Nature. 459:1005–1009, 2009.
Bubendorf, L., et al. Metastatic patterns of prostate cancer: an autopsy study of 1589 patients. Hum. Pathol. 31:578–583, 2000.
Chaudhuri, V., L. Zhou, and M. Karasek. Inflammatory cytokines induce the transformation of human dermal microvascular endothelial cells into myofibroblasts: a potential role in skin fibrogenesis. J. Cutan. Pathol. 34:146–153, 2007.
Deeb, A., S.-U. Haque, and O. Olowokure. Pulmonary metastases in pancreatic cancer, is there a survival influence? J. Gastrointest. Oncol. 6:E48-51, 2015.
Derada Troletti, C., et al. Inflammation-induced endothelial to mesenchymal transition promotes brain endothelial cell dysfunction and occurs during multiple sclerosis pathophysiology. Cell Death Dis. 10:1–13, 2019.
Drolez, A., et al. Selection of a relevant in vitro blood–brain barrier model to investigate Pro-Metastatic features of human breast cancer cell lines. PLoS ONE. 11:1–18, 2016.
Fan, J., and B. M. Fu. Quantification of malignant breast cancer cell MDA-MB-231 transmigration across brain and lung microvascular endothelium. Ann. Biomed. Eng. 44:2189–2201, 2016.
Fares, J., D. Kanojia, A. Rashidi, I. Ulasov, and M.S. Lesniak. Genes that mediate metastasis across the blood–brain barrier. Trends in Cancer 6:660–676, 2020.
Farmaki, E., I. Chatzistamou, V. Kaza, and H. Kiaris. A CCL8 gradient drives breast cancer cell dissemination. Physiol. Behav. 176:139–148, 2017.
Ferreira, F. U., et al. Endothelial cells tissue-specific origins affects their responsiveness to TGF-β2 during endothelial-to-mesenchymal transition. Int. J. Mol. Sci. 20:1–14, 2019.
Gasparics, Á., L. Rosivall, I. A. Krizbai, and A. Sebe. When the endothelium scores an own goal: endothelial cells actively augment metastatic extravasation through endothelial-mesenchymal transition. Am. J. Physiol. Heart Circ. Physiol. 310(9):H1055–H1063, 2016.
Gray, K. M., D. B. Katz, E. G. Brown, and K. M. Stroka. Quantitative phenotyping of cell–cell junctions to evaluate ZO-1 presentation in brain endothelial cells. Ann. Biomed. Eng. 47:1675–1687, 2019.
Hanahan, D., and R. A. Weinberg. Hallmarks of cancer: The next generation. Cell 144:646–674, 2011.
Harati, R., S. Hafezi, A. Mabondzo, and A. Tlili. Silencing miR-202-3p increases MMP-1 and promotes a brain invasive phenotype in metastatic breast cancer cells. PLoS ONE. 15:1–26, 2020.
Haskó, J., et al. Response of the neurovascular unit to brain metastatic breast cancer cells. Acta Neuropathol. Commun. 7:133, 2019.
Heitz, F., et al. Triple-negative and HER2-overexpressing breast cancers exhibit an elevated risk and an earlier occurrence of cerebral metastases. Eur. J. Cancer. 45:2792–2798, 2009.
Herman, H., et al. Paracellular and transcellular migration of metastatic cells through the cerebral endothelium. J. Cell. Mol. Med. 23:2619–2631, 2019.
Hewett, S. J., N. A. Jackman, and R. J. Claycomb. Interleukin-1β in Central Nervous System Injury and Repair. Eur. J. Neurodegener. Dis. 1:195–211, 2012.
Kemper, E. M., W. Boogerd, I. Thuis, J. H. Beijnen, and O. van Tellingen. Modulation of the blood–brain barrier in oncology: therapeutic opportunities for the treatment of brain tumours? Cancer Treat. Rev. 30:415–423, 2004.
Kim, M. O., H. S. Suh, C. F. Brosnan, and S. C. Lee. Regulation of RANTES/CCL5 expression in human astrocytes by interleukin-1 and interferon-β. J. Neurochem. 90:297–308, 2004.
Klein, S., et al. α5β1 Integrin activates an NF-κB-dependent program of gene expression important for angiogenesis and inflammation. Mol. Cell. Biol. 22:5912–5922, 2002.
Krizbai, I. A., et al. Endothelial-mesenchymal transition of brain endothelial cells: possible role during metastatic extravasation. PLoS ONE. 10:1–19, 2015.
Lee, Y. T., and D. A. Geer. Primary liver cancer: pattern of metastasis. J. Surg. Oncol. 36:26–31, 1987.
Li, J. Y., et al. The chemokine receptor CCR4 promotes tumor growth and lung metastasis in breast cancer. Breast Cancer Res. Treat. 131:837–848, 2012.
Lim, S. Y., A. E. Yuzhalin, A. N. Gordon-Weeks, and R. J. Muschel. Targeting the CCL2-CCR2 signaling axis in cancer metastasis. Oncotarget. 7:28697–28710, 2016.
Lin, C.-C., and B. T. Edelson. New insights into the role of IL-1β in experimental autoimmune encephalomyelitis and multiple sclerosis. J. Immunol. 198:4553–4560, 2017.
Lippmann, E. S., A. Al-Ahmad, S. M. Azarin, S. P. Palecek, and E. V. Shusta. A retinoic acid-enhanced, multicellular human blood–brain barrier model derived from stem cell sources. Sci. Rep. 4:4160, 2014.
Lippmann, E. S., S. M. Azarin, S. P. Palecek, and E. V. Shusta. Commentary on human pluripotent stem cell-based blood–brain barrier models. Fluids Barriers CNS BioMed Central. 17:4–9, 2020.
Lorger, M., and B. Felding-Habermann. Capturing changes in the brain microenvironment during initial steps of breast cancer brain metastasis. Am. J. Pathol. 176:2958–2971, 2010.
Lorger, M., H. Lee, J. S. Forsyth, and B. Felding-Habermann. Comparison of in vitro and in vivo approaches to studying brain colonization by breast cancer cells. J. Neurooncol. 104:689–696, 2011.
Maleszewska, M., J. R. A. J. Moonen, N. Huijkman, B. van de Sluis, G. Krenning, and M. C. Harmsen. IL-1β and TGFβ2 synergistically induce endothelial to mesenchymal transition in an NFκB-dependent manner. Immunobiology. 218:443–454, 2013.
McLay, R. N., A. J. Kastin, and J. E. Zadina. Passage of interleukin-1-beta across the blood–brain barrier is reduced in aged mice: a possible mechanism for diminished fever in aging. Neuroimmunomodulation. 8:148–153, 2000.
Miller, S. J. Astrocyte heterogeneity in the adult central nervous system. Front. Cell. Neurosci. 12:1–6, 2018.
Molnár, J., et al. Transmigration characteristics of breast cancer and melanoma cells through the brain endothelium: Role of Rac and PI3K. Cell Adhes. Migr. 10:269–281, 2016.
Motallebnejad, P., and S. M. Azarin. Chemically defined human vascular laminins for biologically relevant culture of hiPSC-derived brain microvascular endothelial cells. Fluids Barriers CNS BioMed Central. 17:1–16, 2020.
Motallebnejad, P., A. Thomas, S. L. Swisher, and S. M. Azarin. An isogenic hiPSC-derived BBB-on-a-chip. Biomicrofluidics. 13:1–13, 2019.
Nibbs, R. J. B., and G. J. Graham. Immune regulation by atypical chemokine receptors. Nat. Rev. Immunol. 13:815–829, 2013.
Nieder, C., O. Spanne, M. P. Mehta, A. L. Grosu, and H. Geinitz. Presentation, patterns of care, and survival in patients with brain metastases: What has changed in the last 20 years? Cancer. 117:2505–2512, 2011.
O’Carroll, S. J., et al. Pro-inflammatory TNFα and IL-1β differentially regulate the inflammatory phenotype of brain microvascular endothelial cells. J. Neuroinflammation. 12:1–18, 2015.
Pan, W., K. P. Stone, H. Hsuchou, V. K. Manda, Y. Zhang, and A. J. Kastin. Cytokine signaling modulates BBB function. Curr Pharm Des. 17:3729–3740, 2014.
Platta, C. S., D. Khuntia, M. P. Mehta, and J. H. Suh. Current treatment strategies for brain metastasis and complications from therapeutic techniques NCF in brain metastasis. Am. J. Clin. Oncol. 33:398–407, 2010.
Pranda, M. A., K. M. Gray, A. J. L. DeCastro, G. M. Dawson, J. W. Jung, and K. M. Stroka. Tumor cell mechanosensing during incorporation into the brain microvascular endothelium. Cell. Mol. Bioeng. 12:455–480, 2019.
Rajaram, M., J. Li, M. Egeblad, and R. S. Powers. System-wide analysis reveals a complex network of tumor-fibroblast interactions involved in tumorigenicity. PLoS Genet. 9:e1003789, 2013.
Rempe, R. G., A. M. S. Hartz, and B. Bauer. Matrix metalloproteinases in the brain and blood–brain barrier: Versatile breakers and makers. J. Cereb. Blood Flow Metab. 36:1481–1507, 2016.
Rieder, F., et al. Inflammation-induced endothelial-to-mesenchymal transition: a novel mechanism of intestinal fibrosis. Am. J. Pathol. 179:2660–2673, 2011.
Romero-Moreno, R., et al. The CXCL5/CXCR2 axis is sufficient to promote breast cancer colonization during bone metastasis. Nat. Commun. 10:4404, 2019.
Rostami, R., S. Mittal, P. Rostami, F. Tavassoli, and B. Jabbari. Brain metastasis in breast cancer: a comprehensive literature review. J. Neurooncol. 127:407–414, 2016.
Sadowska, G. B., et al. Interleukin-1β transfer across the blood–brain barrier in the ovine fetus. J. Cereb. Blood Flow Metab. 35:1388–1395, 2015.
Shaftel, S. S., W. S. T. Griffin, and K. M. Kerry. The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective. J. Neuroinflammation. 5:1–12, 2008.
Shumakovich, M. A., C. P. Mencio, J. S. Siglin, R. A. Moriarty, H. M. Geller, and K. M. Stroka. Astrocytes from the brain microenvironment alter migration and morphology of metastatic breast cancer cells. FASEB J. 31:5049–5067, 2017.
Siegel, R. L., K. D. Miller, and A. Jemal. Cancer statistics, 2020. CA Cancer J. Clin. 70:7–30, 2020.
Skinner, R. A., R. M. Gibson, N. J. Rothwell, E. Pinteaux, and J. I. Penny. Transport of interleukin-1 across cerebromicrovascular endothelial cells. Br. J. Pharmacol. 156:1115–1123, 2009.
Spampinato, S. F., V. Bortolotto, P. L. Canonico, M. A. Sortino, and M. Grilli. Astrocyte-derived paracrine signals: relevance for neurogenic niche regulation and blood–brain barrier integrity. Front. Pharmacol. 10:1–9, 2019.
Stamatovic, S. M., A. M. Johnson, R. F. Keep, and A. V. Andjelkovic. Junctional proteins of the blood–brain barrier: new insights into function and dysfunction. Tissue Barriers. 4:1–12, 2016.
Stebbins, M. J., H. K. Wilson, S. G. Canfield, T. Qian, S. P. Palecek, and E. V. Shusta. Differentiation and characterization of human pluripotent stem cell-derived brain microvascular endothelial cells. Methods. 101:93–102, 2015.
Tulotta, C., et al. Endogenous production of IL1B by breast cancer cells drives metastasis and colonization of the bone microenvironment. Clin. Cancer Res. 25:2769–2782, 2019.
Tulotta, C., and P. Ottewell. The role of IL-1B in breast cancer bone metastasis. Endocr. Relat. Cancer. 25:R421–R434, 2018.
Uhlén, M., et al. The human secretome. Sci. Signal. 12:1–9, 2019.
Vacchini, A., M. Locati, and E. M. Borroni. Overview and potential unifying themes of the atypical chemokine receptor family. J. Leukoc. Biol. 99:883–892, 2016.
Valiente, M., et al. Serpins promote cancer cell survival and vascular co-option in brain metastasis. Cell. 156:1002–1016, 2014.
Wang, L., et al. Astrocytes directly influence tumor cell invasion and metastasis in vivo. PLoS ONE. 8:e80933, 2013.
Wasilewski, D., Priego, N., Fustero-Torre, C., and M. Valiente. Reactive astrocytes in brain metastasis. Front. Oncol. 7:1–12, 2017.
Wrobel, J. K., and M. Toborek. Blood–brain barrier remodeling during brain metastasis formation. Mol. Med. 22:32–40, 2016.
Xing, F., et al. Reactive astrocytes promote the metastatic growth of breast cancer stem-like cells by activating Notch signalling in brain. EMBO Mol. Med. 5(3):384–396, 2013.
Xing, F., et al. MiR-509 suppresses brain metastasis of breast cancer cells by modulating RhoC and TNF-α. Oncogene. 34:4890–4900, 2015.
Xing, F., et al. Activation of the c-Met pathway mobilizes an inflammatory network in the brain microenvironment to promote brain metastasis of breast cancer. Cancer Res. 76:4970–4980, 2016.
Xu, H., Z. Li, Y. Yu, S. Sizdahkhani, W. S. Ho, and F. Yin. A dynamic in vivo-like organotypic blood–brain barrier model to probe metastatic brain tumors. Sci. Rep. 6:1–12, 2016.
Yang, C., et al. CXCL1 stimulates migration and invasion in ER-negative breast cancer cells via activation of the ERK/MMP2/9 signaling axis. Int. J. Oncol. 55:684–696, 2019.