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Nuclear Lamins in Cancer

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Abstract

Dysmorphic nuclei are commonly seen in cancers and provide strong motivation for studying in various cancer contexts the main structural proteins of nuclei, the lamins. Past studies have separately demonstrated the importance of microenvironment mechanics to cancer progression, which is extremely interesting because the lamina was recently shown to be mechanosensitive. Here, we review current knowledge relating cancer progression to lamina biophysics and biology. Lamin levels can modulate cancer cell migration in 3D and thereby impact tumor growth, and lamins can also protect or not a cancer cell’s genome. In addition, lamins can influence transcriptional regulators (RAR, SRF, YAP/TAZ) as well as chromosome conformation in lamina associated domains. Further investigation of the roles for lamins in cancer and even DNA damage may lead to new therapies or at least to a clearer understanding of lamins as bio-markers in cancer progression.

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Acknowledgments

The authors in this review were supported by a Physical Sciences in Oncology Center grant from the National Cancer Institute of the National Institutes of Health under Award Number U54CA193417. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Conflict of interest

Jerome Irianto, Charlotte R. Pfeifer, Irena L. Ivanovska, Joe Swift, and Dennis E. Discher declare that they have no conflicts of interest.

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No human studies were carried out by authors for this article. No animal studies were carried out by authors for this article.

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  1. Molecular and Cell Biophysics Lab and Physical Sciences Oncology Center, University of Pennsylvania, 129 Towne Bldg, Philadelphia, PA, 19104-6393, USA

    Jerome Irianto, Charlotte R. Pfeifer, Irena L. Ivanovska, Joe Swift & Dennis E. Discher

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  1. Jerome Irianto
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  2. Charlotte R. Pfeifer
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Correspondence to Dennis E. Discher.

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Associate Editor Kris Noel Dahl oversaw the review of this article.

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Irianto, J., Pfeifer, C.R., Ivanovska, I.L. et al. Nuclear Lamins in Cancer. Cel. Mol. Bioeng. 9, 258–267 (2016). https://doi.org/10.1007/s12195-016-0437-8

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