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Synergistic Regulation of Angiogenic Sprouting by Biochemical Factors and Wall Shear Stress

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Abstract

The process of sprouting angiogenesis involves activating endothelial cells (ECs) in a quiescent monolayer of an existing vessel to degrade and migrate into the underlying matrix to form new blood vessels. While the roles of biochemical factors in angiogenic sprouting have been well characterized, the roles of fluid forces have received much less attention. This review summarizes results that support a role for wall shear stress in post-capillary venules as a mechanical factor capable of synergizing with biochemical factors to stimulate pro-angiogenic signaling in ECs and promote sprout formation.

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Acknowledgments

This work was supported by American Heart Association Scientist Development Grant #0730238N (RRK) and NIH R01HL09576 (KJB).

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Authors and Affiliations

  1. Department of Biomedical Engineering, Texas A&M University, 337 Zachry Engineering Center, College Station, TX, 77843-3120, USA

    Roland Kaunas & Hojin Kang

  2. Department of Molecular and Cellular Medicine, Texas A&M Health Science Center, 440 Reynolds Medical Bldg., College Station, TX, 77843-1114, USA

    Kayla J. Bayless

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  1. Roland Kaunas
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  2. Hojin Kang
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Correspondence to Roland Kaunas or Kayla J. Bayless.

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Associate Editor John Shyy and Yingxiao Wang oversaw the review of this article.

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Kaunas, R., Kang, H. & Bayless, K.J. Synergistic Regulation of Angiogenic Sprouting by Biochemical Factors and Wall Shear Stress. Cel. Mol. Bioeng. 4, 547–559 (2011). https://doi.org/10.1007/s12195-011-0208-5

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