References
Saito S, Takahashi Y, Ohki A, Shintani Y, Higuchi T. Early detection of elevated lactate levels in a mitochondrial disease model using chemical exchange saturation transfer (CEST) and magnetic resonance spectroscopy (MRS) at 7 T-MRI. Radiol Phys Technol. 2018. https://doi.org/10.1007/s12194-018-0490-1.
Finsterer J. Leigh and Leigh-like syndrome in children and adults. Pediatr Neurol. 2008;39:223–35.
Lunsing RJ, Strating K, de Koning TJ, Sijens PE. Diagnostic value of MRS-quantified brain tissue lactate level in identifying children with mitochondrial disorders. Eur Radiol. 2017;27:976–84.
Lamont RE, Beaulieu CL, Bernier FP, Sparkes R, Innes AM, Jackel-Cram C, Ober C, Parboosingh JS, Lemire EG. A novel NDUFS4 frameshift mutation causes Leigh disease in the Hutterite population. Am J Med Genet A. 2017;173:596–600.
DeBrosse C, Nanga RP, Bagga P, Nath K, Haris M, Marincola F, Schnall MD, Hariharan H, Reddy R. Lactate chemical exchange saturation transfer (LATEST) imaging in vivo a biomarker for LDH activity. Sci Rep. 2016;6:19517. https://doi.org/10.1038/srep19517.
Funding
None received.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
There are no conflicts of interest.
Ethical standards
International ethical standards were met.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
About this article
Cite this article
Finsterer, J. Early-age Ndufs4 knockout mice are an inappropriate animal model of Leigh syndrome. Radiol Phys Technol 12, 230–231 (2019). https://doi.org/10.1007/s12194-019-00511-z
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12194-019-00511-z