Abstract
Heat shock protein 90 is a highly conserved molecular chaperone, essential for cellular survival under diverse environments. Since this protein is employed by tumors to promote their prevalence, heat shock protein 90 inhibitors have been developed to oppose malignancies. The anti-cancer effects of those compounds appear to be associated with anti-inflammatory properties. Thus, ongoing laborious efforts investigate the possible application of those agents towards inflammatory disorders of the lungs, such as the acute respiratory distress syndrome.
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Funding
This research is supported by the R&D, Research Competitiveness Subprogram (RCS) of the Louisiana Board of Regents through the Board of Regents Support Fund (LEQSF (2019-22)-RD-A-26) (PI:NB), and by the National Institute of General Medical Sciences (NIGMS) of the National Institute of Health (NIH) (5 P20GM103424-15, 3 P20GM103424-15S1).
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Barabutis, N. Heat shock protein 90 inhibition in the inflamed lungs. Cell Stress and Chaperones 25, 195–197 (2020). https://doi.org/10.1007/s12192-020-01069-1
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DOI: https://doi.org/10.1007/s12192-020-01069-1