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Mediators and mechanisms of heat shock protein 70 based cytoprotection in obstructive nephropathy

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Cell Stress and Chaperones Aims and scope

Abstract

Urinary heat shock protein 70 (Hsp70) is rapidly increased in patients with clinical acute kidney injury, indicating that it constitutes a component of the endogenous stress response to renal injury. Moreover, experimental models have demonstrated that Hsp70 activation is associated with the cytoprotective actions of several drugs following obstruction, including nitric oxide (NO) donors, geranylgeranylacetone, vitamin D, and rosuvastatin. Discrete and synergistic effects of the biological activities of Hsp70 may explain its cytoprotective role in obstructive nephropathy. Basic studies point to a combination of effects including inhibition of apoptosis and inflammation, repair of damaged proteins, prevention of unfolded protein aggregation, targeting of damaged protein for degradation, and cytoskeletal stabilization as primary effectors of Hsp70 action. This review summarizes our understanding of how the biological actions of Hsp70 may affect renal cytoprotection in the context of obstructive injury. The potential of Hsp70 to be of central importance to the mechanism of action of various drugs that modify the genesis of experimental obstructive nephropathy is considered.

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Acknowledgments

Our thanks to Claudia Bottero for improving the style and grammar of the text.

Funding

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by grants from the Research and Technology Council of Cuyo University (SECyT), Mendoza, Argentina, and from the National Council of Scientific and Technical Research (CONICET) PIP 2010-2012, both of which were awarded to Walter Manucha. Grant no. PICT 2012-0234 Préstamo BID 2777 OC/AR.

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Authors and Affiliations

  1. Área de Farmacología, Departamento de Patología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina

    Luciana Mazzei & Walter Manucha

  2. IMBECU-CONICET (National Council of Scientific and Technical Research of Argentina), Buenos Aires, Argentina

    Luciana Mazzei & Walter Manucha

  3. Conway Institute of Biomolecular and Biomedical Research, School of Medicine and Medical Science, University College Dublin, Dublin, Ireland

    Neil G. Docherty

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  1. Luciana Mazzei
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  2. Neil G. Docherty
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  3. Walter Manucha
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Correspondence to Luciana Mazzei.

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Mazzei, L., Docherty, N.G. & Manucha, W. Mediators and mechanisms of heat shock protein 70 based cytoprotection in obstructive nephropathy. Cell Stress and Chaperones 20, 893–906 (2015). https://doi.org/10.1007/s12192-015-0622-z

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  • DOI: https://doi.org/10.1007/s12192-015-0622-z

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