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Serum levels of heat shock protein 27 in patients with acute ischemic stroke

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Cell Stress and Chaperones Aims and scope

Abstract

Expression of intracellular heat shock protein 27 (Hsp27) rises in the brain of animal models of cerebral ischemia and stroke. Hsp27 is also released into the circulation and the aim of the present study was to investigated if serum Hsp27 (sHsp27) levels are altered in patients with acute ischemic stroke. sHsp27 was measured in 15 patients with acute ischemic stroke and in 14 control subjects comparable for age, sex, and cardiovascular risk factors. In patients, measurements were performed at admission and 1, 2, and 30 days thereafter. At admission, mean sHsp27 values were threefold higher in patients than in controls. In patients, sHsp27 values dropped after 24 h, rose again at 48 h, and markedly declined at 30 days, indicating the presence of a temporal trend of sHsp27 values following acute ischemic stroke.

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Acknowledgments

This study is supported by grants from the Piedmont Region and the University of Turin.

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Authors and Affiliations

  1. Department of Medical Science, University of Turin, C/so Dogliotti 14, 10126, Turin, Italy

    Gabriella Gruden, Federica Barutta, Irene Catto, Silvia Pinach, Paolo Fornengo, Paolo Cavallo-Perin & Graziella Bruno

  2. Stroke Unit, San Giovanni Battista Hospital, Turin, Italy

    Giovanni Bosco, Maria Giovanna Caprioli & Paolo Cerrato

  3. Radiology 2 - San Giovanni Battista Hospital, Turin, Italy

    Ottavio Davini

Authors
  1. Gabriella Gruden
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  2. Federica Barutta
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  3. Irene Catto
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  4. Giovanni Bosco
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  5. Maria Giovanna Caprioli
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  6. Silvia Pinach
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  7. Paolo Fornengo
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  8. Paolo Cavallo-Perin
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  9. Ottavio Davini
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  10. Paolo Cerrato
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  11. Graziella Bruno
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Corresponding author

Correspondence to Gabriella Gruden.

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Gruden, G., Barutta, F., Catto, I. et al. Serum levels of heat shock protein 27 in patients with acute ischemic stroke. Cell Stress and Chaperones 18, 531–533 (2013). https://doi.org/10.1007/s12192-013-0403-5

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  • DOI: https://doi.org/10.1007/s12192-013-0403-5

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