Cell Stress and Chaperones

, Volume 17, Issue 6, pp 647–655 | Cite as

Loss of stress response as a consequence of viral infection: implications for disease and therapy

  • Philip L. Hooper
  • Lawrence E. Hightower
  • Paul L. Hooper
Perspective and Reflection Article


Herein, we propose that viral infection can induce a deficient cell stress response and thereby impairs stress tolerance and makes tissues vulnerable to damage. Having a valid paradigm to address the pathological impacts of viral infections could lead to effective new therapies for diseases that have previously been unresponsive to intervention. Host response to viral infections can also lead to autoimmune diseases like type 1 diabetes. In the case of Newcastle disease virus, the effects of viral infection on heat shock proteins may be leveraged as a therapy for cancer. Finally, the search for a specific virus being responsible for a condition like chronic fatigue syndrome may not be worthwhile if the disease is simply a nonspecific response to viral infection.


Influenza West Nile Virus Chronic Fatigue Syndrome Unfold Protein Response Newcastle Disease Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Cell Stress Society International 2012

Authors and Affiliations

  • Philip L. Hooper
    • 1
  • Lawrence E. Hightower
    • 2
  • Paul L. Hooper
    • 3
    • 4
  1. 1.Division of Endocrinology, Metabolism, and Diabetes, School of MedicineUniversity of ColoradoAuroraUSA
  2. 2.Department of Molecular and Cell BiologyUniversity of ConnecticutStorrsUSA
  3. 3.Department of AnthropologyUniversity of New MexicoAlbuquerqueUSA
  4. 4.Santa Fe InstituteSanta FeUSA

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