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Lymphoma during pregnancy in Japan: a multicenter retrospective cohort study

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International Journal of Hematology Aims and scope Submit manuscript

Abstract

Objective

This study was conducted to characterize lymphoma occurring during pregnancy and to investigate the outcomes of the patients and the fetuses.

Methods

Clinical data were gathered retrospectively from 29 patients at 13 participating institutions, and data from 28 eligible patients were analyzed.

Results

Six (21%) patients had Hodgkin lymphoma (HL) and 22 (79%) patients had non-Hodgkin lymphoma (NHL). All patients with HL presented with lymphadenopathy, but 15 (68%) of the 22 patients with NHL presented with extranodal sites only. At the median follow-up period of 1325 (range 6–4461) days, the 5-year overall survival rate was 63% for patients with NHL and 100% for patients with HL. Three of the 13 patients who received chemotherapy during pregnancy (23%) developed Pneumocystis jiroveci pneumonia (PCP). There was 1 intrauterine fetal death, 1 spontaneous abortion in the first trimester, and 15 (54%) preterm births.

Conclusion

This study showed a higher proportion of NHL than HL during pregnancy in Japan, which was inconsistent with the proportions observed in Western countries. The high incidence of maternal PCP and preterm birth suggested the need for improvements in our management of lymphoma during pregnancy.

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Acknowledgements

We appreciate all the patients who participated in this study and the collaborators who collected valuable patient data, and we pray for the healthy growth of the children born to these courageous mothers. This work was supported by “Shimane University Grants for Joint Research Project led by Female Researchers” under the Ministry of Education, Culture, Sports, Science and Technology (MEXT) “Initiative for Realizing Diversity in the Research Environment (Collaboration Type)”.

Funding

This work was funded by Ministry of Education, Culture, Sports, Science and Technology.

Author information

Authors and Affiliations

  1. Clinical Research Center, Shimane University Hospital, 89-1 Enya Cho, Izumo, Shimane, 693-8501, Japan

    Chie Onishi

  2. Department of Hematology/Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

    Momoko Nishikori

  3. Department of Medical Oncology and Hematology, Kobe University Hospital, Kobe, Japan

    Kimikazu Yakushijin

  4. Department of Hematology and Oncology, Toyohashi Municipal Hospital, Toyohashi, Japan

    Shingo Kurahashi

  5. Division of Hematology, Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan

    Hideyuki Nakazawa

  6. Division of Medical Oncology, Hematology and Infectious Diseases, Department of Internal of Medicine, Fukuoka University, Fukuoka, Japan

    Yasushi Takamatsu

  7. Department of Hematology, Tottori Prefectural Central Hospital, Tottori, Japan

    Yoshinori Hashimoto

  8. Department of Hematology, Juntendo University School of Medicine, Tokyo, Japan

    Yoshinori Hashimoto

  9. Department of Hematology, Rheumatology and Infectious Diseases, Kumamoto University Hospital, Kumamoto, Japan

    Hiro Tatetsu

  10. Division of Hematology, Ehime Prefectural Central Hospital, Matsuyama, Japan

    Yuichiro Nawa

  11. Department of Hematology, Osaka City General Hospital, Osaka, Japan

    Masahiro Yoshida

  12. Division of Hematology and Oncology, Kyoto Prefectural University of Medicine, Kyoto, Japan

    Tsutomu Kobayashi

  13. Division of Hematology and Oncology, Department of Internal Medicine, Iwate Medical University School of Medicine, Morioka, Japan

    Tatsuo Oyake

  14. Division of Clinical Oncology and Hematology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan

    Shingo Yano

  15. Department of Obstetrics and Gynecology, Faculty of Medicine, Shimane University, Izumo, Japan

    Aki Oride

  16. Department of Hematology, Shimane University Hospital, Izumo, Japan

    Ritsuro Suzuki

Authors
  1. Chie Onishi
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  2. Momoko Nishikori
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  3. Kimikazu Yakushijin
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  4. Shingo Kurahashi
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  5. Hideyuki Nakazawa
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  8. Hiro Tatetsu
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  9. Yuichiro Nawa
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  11. Tsutomu Kobayashi
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  13. Shingo Yano
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  14. Aki Oride
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  15. Ritsuro Suzuki
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Corresponding author

Correspondence to Chie Onishi.

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Onishi, C., Nishikori, M., Yakushijin, K. et al. Lymphoma during pregnancy in Japan: a multicenter retrospective cohort study. Int J Hematol 115, 382–390 (2022). https://doi.org/10.1007/s12185-021-03281-w

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  • DOI: https://doi.org/10.1007/s12185-021-03281-w

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