Abstract
Acute pancreatitis (AP) is a potential complication of hematopoietic stem cell transplantation (HSCT), but its incidence and risk factors remain unclear. Thus, we reviewed the cases of 259 consecutive children who received allogeneic HSCT at our institution between January 2000 and December 2017 to determine the incidence and risk factors of AP. Thirteen patients developed AP during a median follow-up period of 4.4 years. The median time from HSCT to AP onset was 80 days (range 29–2426 days), and cumulative incidence (CI) at 4 years was 5.0% [95% confidence interval (95% CI) 2.7–8.3%]. The CI of AP was significantly higher in patients who received bone marrow or peripheral blood stem cells than in those who received cord blood (7.2% versus 0.0% at 4 years, P = 0.02) and was higher in patients who developed grade II–IV acute graft-versus-host disease (GVHD) than in those who did not (31.4% versus 1.4% at 4 years, P < 0.001). Multivariate analysis showed that grade II–IV acute GVHD was an independent risk factor for AP [hazard ratio 15.2 (95% CI 4.1–55.8), P < 0.001] and was strongly associated with post-HSCT AP in children.
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Acknowledgements
The authors thank all staffs who contributed to patient care at our institute.
This research was funded by Japanese Red Cross Nagoya First Hospital Research Grant NFRCH20-0035.
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This research was funded by Japanese Red Cross Nagoya First Hospital Research Grant NFRCH20-0035.
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D.S., H.S., N.Y., and A.H. designed the research, analyzed the data, and wrote the manuscript. D.Y., R.M., and H.K. collected the clinical data. All authors discussed the results and commented on the manuscript.
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Sajiki, D., Yamashita, D., Maemura, R. et al. Acute pancreatitis following allogeneic hematopoietic stem cell transplantation in children. Int J Hematol 114, 494–501 (2021). https://doi.org/10.1007/s12185-021-03195-7
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DOI: https://doi.org/10.1007/s12185-021-03195-7