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Cutaneous T-cell lymphoma in Asian patients: a multinational, multicenter, prospective registry study in Asia

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Abstract

Cutaneous T-cell lymphomas (CTCLs) are a group of T-cell lymphomas with low incidence. Due to their indolent characteristics, treatment strategies have not yet been established for advanced CTCLs. In this study, relative incidence of CTCLs in Asia was estimated and the therapeutic outcomes presented based on various treatments currently used in clinics for advanced CTCLs. As part of a prospective registry study of peripheral T-cell lymphoma (PTCL) conducted across Asia, including Korea, China, Taiwan, Singapore, Malaysia, and Indonesia, subgroup analysis was performed for patients with CTCLs. Among 486 patients with PTCL, 37 with CTCL (7.6%) were identified between April 2016 and February 2019. Primary cutaneous ALK-negative anaplastic large cell lymphoma (ALCL, 35.1%) was the most common subtype. With a median follow-up period of 32.1 months, median progression-free survival (PFS) was 53.5 months (95% CI 0.0–122.5), and overall survival was not reached. 14 patients (48.2%) underwent subsequent treatment after the first relapse, but the response rate was 20% with a PFS of 2.2 months (95% CI 0.3–4.0). Six patients received autologous stem cell transplantation (auto-SCT). However, auto-SCT did not result in better outcomes. Additional studies are needed on standard care treatment of advanced or refractory and relapsed CTCLs.

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References

  1. Willemze R, Jaffe ES, Burg G, Cerroni L, Berti E, Swerdlow SH, et al. WHO-EORTC classification for cutaneous lymphomas. Blood. 2005;105(10):3768–85.

    Article  CAS  Google Scholar 

  2. Willemze R, Cerroni L, Kempf W, Berti E, Facchetti F, Swerdlow SH, et al. The 2018 update of the WHO-EORTC classification for primary cutaneous lymphomas. Blood. 2019;133(16):1703–14.

    Article  CAS  Google Scholar 

  3. Park HS, McIntosh L, Braschi-Amirfarzan M, Shinagare AB, Krajewski KM. T-cell non-hodgkin lymphomas: spectrum of disease and the role of imaging in the management of common subtypes. Korean J Radiol. 2017;18(1):71–83.

    Article  Google Scholar 

  4. Bradford PT, Devesa SS, Anderson WF, Toro JR. Cutaneous lymphoma incidence patterns in the United States: a population-based study of 3884 cases. Blood. 2009;113(21):5064–73.

    Article  CAS  Google Scholar 

  5. Litvinov IV, Tetzlaff MT, Rahme E, Jennings MA, Risser DR, Gangar P, et al. Demographic patterns of cutaneous T-cell lymphoma incidence in Texas based on two different cancer registries. Cancer Med. 2015;4(9):1440–7.

    Article  Google Scholar 

  6. Wilson LD, Hinds GA, Yu JB. Age, race, sex, stage, and incidence of cutaneous lymphoma. Clin Lymphoma Myeloma Leuk. 2012;12(5):291–6.

    Article  Google Scholar 

  7. Pulitzer M. Cutaneous T-cell lymphoma. Clin Lab Med. 2017;37(3):527–46.

    Article  Google Scholar 

  8. Jang MS, Kang DY, Park JB, Kim ST, Suh KS. Cutaneous T-cell lymphoma in Asians. ISRN Dermatol. 2012;2012:575120.

    Article  Google Scholar 

  9. Lansigan F, Foss FM. Current and emerging treatment strategies for cutaneous T-cell lymphoma. Drugs. 2010;70(3):273–86.

    Article  CAS  Google Scholar 

  10. Choi J, Goh G, Walradt T, Hong BS, Bunick CG, Chen K, et al. Genomic landscape of cutaneous T cell lymphoma. Nat Genet. 2015;47(9):1011–9.

    Article  CAS  Google Scholar 

  11. Chung CG, Poligone B. Other chemotherapeutic agents in cutaneous T-cell lymphoma. Dermatol Clin. 2015;33(4):787–805.

    Article  CAS  Google Scholar 

  12. Campo E, Swerdlow SH, Harris NL, Pileri S, Stein H, Jaffe ES. The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications. Blood. 2011;117(19):5019–32.

    Article  CAS  Google Scholar 

  13. Agar NS, Wedgeworth E, Crichton S, Mitchell TJ, Cox M, Ferreira S, et al. Survival outcomes and prognostic factors in mycosis fungoides/Sézary syndrome: validation of the revised International society for cutaneous lymphomas/European organisation for research and treatment of cancer staging proposal. J Clin Oncol. 2010;28(31):4730–9.

    Article  Google Scholar 

  14. Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E, et al. Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification. J Clin Oncol. 2014;32(27):3059–68.

    Article  Google Scholar 

  15. Stevens SR, Ke MS, Parry EJ, Mark J, Cooper KD. Quantifying skin disease burden in mycosis fungoides-type cutaneous T-cell lymphomas: the severity-weighted assessment tool (SWAT). Arch Dermatol. 2002;138(1):42–8.

    Article  Google Scholar 

  16. Kim YH, Willemze R, Pimpinelli N, Whittaker S, Olsen EA, Ranki A, et al. TNM classification system for primary cutaneous lymphomas other than mycosis fungoides and Sezary syndrome: a proposal of the international society for cutaneous lymphomas (ISCL) and the cutaneous lymphoma task force of the European organization of research and treatment of cancer (EORTC). Blood. 2007;110(2):479–84.

    Article  CAS  Google Scholar 

  17. Kelati A, Gallouj S, Tahiri L, Harmouche T, Mernissi FZ. Defining the mimics and clinico-histological diagnosis criteria for mycosis fungoides to minimize misdiagnosis. Int J Womens Dermatol. 2017;3(2):100–6.

    Article  CAS  Google Scholar 

  18. Oschlies I, Klapper W. Mycosis fungoides or inflammatory dermatitis: differential diagnosis between early lymphoma and inflammation in skin biopsies. Pathologe. 2013;34(3):215–24.

    Article  CAS  Google Scholar 

  19. Diwan AH. The challenge of diagnosing mycosis fungoides. Am J Dermatopathol. 2016;38(7):567–8.

    Article  Google Scholar 

  20. Fauconneau A, Pham-Ledard A, Cappellen D, Frison E, Prochazkova-Carlotti M, Parrens M, et al. Assessment of diagnostic criteria between primary cutaneous anaplastic large-cell lymphoma and CD30-rich transformed mycosis fungoides; a study of 66 cases. Br J Dermatol. 2015;172(6):1547–54.

    Article  CAS  Google Scholar 

  21. Kohrt H, Advani R. Extranodal natural killer/T-cell lymphoma: current concepts in biology and treatment. Leuk Lymphoma. 2009;50(11):1773–84.

    Article  CAS  Google Scholar 

  22. Savage KJ, Chhanabhai M, Gascoyne RD, Connors JM. Characterization of peripheral T-cell lymphomas in a single North American institution by the WHO classification. Ann Oncol. 2004;15(10):1467–75.

    Article  CAS  Google Scholar 

  23. Chang LW, Patrone CC, Yang W, Rabionet R, Gallardo F, Espinet B, et al. An integrated data resource for genomic analysis of cutaneous T-cell lymphoma. J Invest Dermatol. 2018;138(12):2681–3.

    Article  CAS  Google Scholar 

  24. Virmani P, Zain J, Rosen ST, Myskowski PL, Querfeld C. Hematopoietic stem cell transplant for mycosis fungoides and Sézary syndrome. Dermatol Clin. 2015;33(4):807–18.

    Article  CAS  Google Scholar 

  25. Atilla E, Atilla PA, Bozdag SC, Yuksel MK, Toprak SK, Topcuoglu P, et al. Allogeneic hematopoietic stem cell transplantation for refractory mycosis fungoides (MF) and Sezary syndrome (SS). Int J Hematol. 2017;106(3):426–30.

    Article  Google Scholar 

  26. Wu PA, Kim YH, Lavori PW, Hoppe RT, Stockerl-Goldstein KE. A meta-analysis of patients receiving allogeneic or autologous hematopoietic stem cell transplant in mycosis fungoides and Sézary syndrome. Biol Blood Marrow Transplant. 2009;15(8):982–90.

    Article  Google Scholar 

  27. Olavarria E, Child F, Woolford A, Whittaker SJ, Davis JG, McDonald C, et al. T-cell depletion and autologous stem cell transplantation in the management of tumour stage mycosis fungoides with peripheral blood involvement. Br J Haematol. 2001;114(3):624–31.

    Article  CAS  Google Scholar 

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Author information

Author notes

  1. Yong-Pyo Lee, Sang Eun Yoon: contributed equally to this work as co-first authors.

  2. Zhu Jun, Won Seog Kim: contributed equally to this work.

Authors and Affiliations

  1. Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81, Irwon-ro, Gangnam-Gu, Seoul, 06351, Korea

    Yong-Pyo Lee, Sang Eun Yoon, Seok Jin Kim & Won Seog Kim

  2. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma, Peking University Cancer Hospital and Institute, Beijing, 100142, China

    Yuqin Song & Zhu Jun

  3. Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea

    Dok Hyun Yoon

  4. National Cheng Kung University Hospital, Tainan, Taiwan

    Tsai-Yun Chen

  5. Department of Internal Medicine, Seoul National University Hospital, Seoul National University School of Medicine, Seoul, South Korea

    Young Il Koh

  6. Division of Hematology and Oncology, Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea

    Ka Won Kang

  7. Division of Hematology-Oncology, Kosin University Gospel Hospital, Busan, South Korea

    Ho sup Lee

  8. Oncocare Cancer Center, Tanglin, Singapore

    Kevin Tay Kuang Wei

  9. National Cancer Centre, Tanjong Pagar, Singapore

    Soon Thye Lim

  10. Department of Haematology-Oncology, National University Health System, Queenstown, Singapore

    Michelle Poon

  11. Indonesia Cipto Mangunkusumo National Central General Hospital, Central Jakarta, Indonesia

    Cosphiadi Irawan

  12. Ruijin Hospital, Shanghai, China

    Weili Zhao

  13. Division of Hematology and Oncology, Department of Internal Medicine, Dongsan Medical Center, Keimyung University College of Medicine, Daegu, South Korea

    Young Rok Do

  14. Department of Hematology-Oncology, Konkuk University Medical Center, Seoul, Korea

    Mark Hong Lee

  15. Subang Jaya Medical Center, Kuala Lumpur, Malaysia

    Soo Chin Ng

  16. Division of Hemato-Oncology, Department of Internal Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, South Korea

    Won-Sik Lee

  17. Fudan University Shanghai Cancer Center, Shanghai, China

    Ye Guo

  18. Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

    Huilai Zhang

  19. Division of Hematology/Oncology, Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, South Korea

    Hye-Jin Kang

  20. Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, South Korea

    Hwan Jung Yun

  21. Division of Hematology and Oncology, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, South Korea

    Hyo Jung Kim

  22. Raffles Cancer Centre, 585 North Bridge Rd, Singapore

    Daryl Tan Chen Lung

  23. Division of Hematology-Oncology, Department of Internal Medicine, Jeonbuk National University Hospital, Jeonbuk National University, Chonju, South Korea

    Jae-Yong Kwak

  24. Department of Hematology and Medical Oncology, College of Medicine, Kyung Hee University, Seoul, South Korea

    Jae Joon Han

  25. Division of Hematology-Oncology, Ewha Womans University Mokdong Hospital, Ewha Womans University, Seoul, South Korea

    Yeung-Chul Mun

  26. Division of Hematology and Oncology, Department of Internal Medicine, Dong-A University Hospital, Dong-A University College of Medicine, Busan, South Korea

    Sung Yong Oh

  27. Department of Internal Medicine, Wonkwang University School of Medicine, Iksan, South Korea

    Hyeok Shim

  28. Department of Internal Medicine, Division of Hemato-Oncology, Kangdong Sacred Heart Hospital, Hallym University, Seoul, South Korea

    Jung Hye Kwon

  29. Department of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, South Korea

    Byeong Seok Sohn

  30. Department of Internal Medicine, Soonchunhyang University College of Medicine, Puchon, South Korea

    Seong Kyu Park

  31. Division of Hematology and Oncology, Department of Internal Medicine, Ulsan University Hospital, Ulsan University College of Medicine, Ulsan, South Korea

    Jae Cheol Jo

  32. Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

    Young Hyeh Ko

Authors
  1. Yong-Pyo Lee
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  2. Sang Eun Yoon
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  3. Yuqin Song
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  4. Seok Jin Kim
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  5. Dok Hyun Yoon
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  6. Tsai-Yun Chen
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  7. Young Il Koh
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  8. Ka Won Kang
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  9. Ho sup Lee
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  10. Kevin Tay Kuang Wei
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  11. Soon Thye Lim
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  12. Michelle Poon
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  13. Cosphiadi Irawan
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  14. Weili Zhao
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  15. Young Rok Do
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  16. Mark Hong Lee
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  17. Soo Chin Ng
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  18. Won-Sik Lee
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  19. Ye Guo
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  20. Huilai Zhang
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  21. Hye-Jin Kang
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  27. Yeung-Chul Mun
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  29. Hyeok Shim
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  32. Seong Kyu Park
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  33. Jae Cheol Jo
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  34. Young Hyeh Ko
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  35. Zhu Jun
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  36. Won Seog Kim
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Corresponding authors

Correspondence to Zhu Jun or Won Seog Kim.

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This article does not contain any studies with human participants or animals performed by any of the authors. All patients provided informed consent before inclusion in this study.

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Lee, YP., Yoon, S.E., Song, Y. et al. Cutaneous T-cell lymphoma in Asian patients: a multinational, multicenter, prospective registry study in Asia. Int J Hematol 114, 355–362 (2021). https://doi.org/10.1007/s12185-021-03179-7

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  • DOI: https://doi.org/10.1007/s12185-021-03179-7

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