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Refined ultrasonographic criteria for sinusoidal obstruction syndrome after hematopoietic stem cell transplantation

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A Correction to this article was published on 17 February 2023

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Abstract

Hepatic sinusoidal obstruction syndrome (SOS)/veno-occlusive disease is a life-threatening complication after hematopoietic stem cell transplantation (HSCT). We previously reported the efficacy of the Hokkaido Ultrasonography (US)-based scoring system (HokUS-10) for US findings. To establish easier-to-use criteria, we retrospectively evaluated US findings from 441 patients, including 30 patients with SOS using the HokUS-10 scoring system. Using logistic regression analysis, we established the novel diagnostic criteria HokUS-6. In the presence of ascites, US diagnosis was made in the presence of two of the following 6 parameters: moderate amount of ascites, the appearance of a paraumbilical vein blood flow signal, gallbladder wall thickening, portal vein dilatation, portal vein velocity decrease, and hepatic artery resistive index increase. The AUC, sensitivity, and specificity of HokUS-6 were 0.974 (95% confidence interval 0.962–0.990), 95.2%, and 96.9%, respectively. The scores were significantly higher in patients with severe SOS than in those with non-severe SOS (p = 0.013). Furthermore, the scores before HSCT were significantly higher in patients who developed SOS than in controls (p = 0.001). The HokUS-6 is an easy and useful way to diagnose and identify the risk of SOS.

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Authors and Affiliations

  1. Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital, N14 W5, Kita-ku, Sapporo, 060-8648, Japan

    Mutsumi Nishida, Junichi Sugita, Shuichiro Takahashi, Takahito Iwai, Yusuke Kudo, Satomi Omotehara & Takanori Teshima

  2. Diagnostic Center for Sonography, Hokkaido University Hospital, Sapporo, Japan

    Mutsumi Nishida, Takahito Iwai, Megumi Sato, Yusuke Kudo, Satomi Omotehara, Tatsunori Horie, Ryosuke Sakano & Hitoshi Shibuya

  3. Department of Radiological Technology, Hokkaido University Hospital, Sapporo, Japan

    Megumi Sato, Tatsunori Horie & Ryosuke Sakano

  4. Department of Biostatistics, Hokkaido University Hospital, Sapporo, Japan

    Isao Yokota

  5. Department of Pediatrics, Hokkaido University Hospital, Sapporo, Japan

    Akihiro Iguchi

  6. Department of Hematology, Faculty of Medicine, Hokkaido University, Sapporo, Japan

    Takanori Teshima

Authors
  1. Mutsumi Nishida
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  2. Junichi Sugita
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  3. Shuichiro Takahashi
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  4. Takahito Iwai
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  5. Megumi Sato
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  6. Yusuke Kudo
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  7. Satomi Omotehara
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  8. Tatsunori Horie
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  9. Ryosuke Sakano
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  10. Hitoshi Shibuya
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  11. Isao Yokota
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  12. Akihiro Iguchi
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  13. Takanori Teshima
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Contributions

MN participated in the research design, the writing of the paper, the performance of the research, and data analysis. JS and ST participated in research design, the data analysis and the review of the paper. TI, MS, YK, SO, TH and RS participated in the performance of the research. HS and AI participated in the review of the paper. IY and TT participated in the research design, data analysis and the writing and review of the paper.

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Correspondence to Mutsumi Nishida.

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The authors declare no competing financial interests.

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Nishida, M., Sugita, J., Takahashi, S. et al. Refined ultrasonographic criteria for sinusoidal obstruction syndrome after hematopoietic stem cell transplantation. Int J Hematol 114, 94–101 (2021). https://doi.org/10.1007/s12185-021-03137-3

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  • DOI: https://doi.org/10.1007/s12185-021-03137-3

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