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A presentation, treatment, and survival analysis of primary cardiac lymphoma cases reported from 2009 to 2019

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Abstract

The heart is a rare primary site of lymphoma, and cardiac involvement is thought to bring a poorer prognosis. A framework of known clinical presentations, diagnostic features, disease complications, treatments, and outcomes to improve prognostication was constructed by a systematic review in 2011. However, some aspects must be discussed further in light of recent advances in lymphoma research. We collected cardiac lymphoma case reports published from January 2009 to January 2019, collected statistics from each patient, and performed a systematic analysis. The epidemiological characteristics, clinical manifestations, treatments, responses, and survival of primary cardiac lymphoma (PCL) patients are described. We obtained 158 cases of heart lymphoma, of which 101 were defined as PCL. There were more male than female cases. Most cases were diffuse large B-cell lymphoma. Six cases of PCL in cardiac myxomas were described. Patients with arrhythmia had shorter progression-free survival compared those without (HR 0.334, 95% CI 0.112–0.999, log-rank P = 0.042). Surgery did not improve patients’ long-term prognosis or reduce the risk of death within 1 month. These data suggest that central nervous system prophylaxis is necessary. The overall survival was longer than that in data from 1949 to 2009.

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Acknowledgments

We thank Nanjing Medical University and Hangzhou First People’s Hospital for supplying the database.

Funding

This study was supported by the Hangzhou Science and Technology Bureau (No. 20142013A61).

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Authors and Affiliations

  1. Institution and Department, Department of Hematology, Hangzhou First People’s Hospital Affiliated to Nanjing Medical University, Graduate School of Nanjing Medical University, Shangcheng District, No. 261, Huansha Road, Hangzhou, Zhejiang, China

    Haoguang Chen, Shenxian Qian, Pengfei Shi, Lirong Liu & Fan Yang

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  1. Haoguang Chen
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  2. Shenxian Qian
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  3. Pengfei Shi
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  4. Lirong Liu
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Correspondence to Shenxian Qian.

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Chen, H., Qian, S., Shi, P. et al. A presentation, treatment, and survival analysis of primary cardiac lymphoma cases reported from 2009 to 2019. Int J Hematol 112, 65–73 (2020). https://doi.org/10.1007/s12185-020-02881-2

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  • DOI: https://doi.org/10.1007/s12185-020-02881-2

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