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The ontogeny of murine B-1a cells

  • Progress in Hematology
  • B1cells: their ontogeny and malignant counterpart
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Abstract

It has been over 35 years since the discovery of a special subtype of B cells in mice. These IgM+ B cells are named B-1 cells, whereas conventional B cells are referred to as B-2 cells. B-1 cells express Ly-1 (CD5) and CD11b antigen, which are usually expressed in T cells and myeloid cells, respectively, reside mainly in the peritoneal and pleural cavities, and secrete natural IgM antibodies in a T cell-independent manner. B-1 cells are further categorized into CD5+ B-1a cells and CD5– B-1b cells. B-1 cells may develop through positive selection and secrete natural antibodies, including low-affinity-binding autoantibodies. Transplantation assays have revealed that the fetal liver, not the bone marrow (BM), is a major site for the production of B-1a cells, leading to the concept of a fetal origin for B-1a cells. This review introduces how the origin of B-1a cells has been explored, and describes the current state of knowledge gained through various approaches.

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Acknowledgements

We would like to thank Editage (www.editage.com) for English language editing. This study is supported by NIAID R01AI121197.

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  1. Center for Stem Cell and Regenerative Medicine, Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, 1825 Pressler St., Houston, TX, 77030, USA

    Momoko Yoshimoto

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  1. Momoko Yoshimoto
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Correspondence to Momoko Yoshimoto.

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Yoshimoto, M. The ontogeny of murine B-1a cells. Int J Hematol 111, 622–627 (2020). https://doi.org/10.1007/s12185-019-02787-8

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  • DOI: https://doi.org/10.1007/s12185-019-02787-8

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