Discussion on the indication of allogeneic stem cell transplantation for advanced cutaneous T cell lymphomas

Abstract

Advanced cutaneous T cell lymphoma (CTCL) patients have a dismal prognosis, especially those relapsing or progressing after systemic therapy. No curative therapies are available, but some new agents have prolonged disease-free survival time with a good toxicity profile. Allogeneic stem cell transplantation (allo-SCT) offers the longest disease-free survival, potentially representing the best therapeutic option for eligible patients. In the present article, we discuss current evidence about allo-SCT for CTCL patients, timing, and new therapeutic options before allo-SCT, taking into account some considerations that may impact clinical outcome.

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Acknowledgements

This work was supported in part by Grant 2017 SGR 1395 from the Catalan Government, Grant from “Obra Social La Caixa” Barcelona Spain, and grant Tercel RD16/0011/0028 from the Instituto de Salud Carlos III, Ministerio de Economía y Competitividad, Spain.

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Correspondence to Silvana Novelli.

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Novelli, S., Monter, A., Pilar García-Muret, M. et al. Discussion on the indication of allogeneic stem cell transplantation for advanced cutaneous T cell lymphomas. Int J Hematol 110, 406–410 (2019). https://doi.org/10.1007/s12185-019-02707-w

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Keywords

  • Cutaneous T cell lymphoma
  • Mycosis fungoide
  • Sézary syndrome
  • Allogeneic hematopoietic transplantation