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Clinicopathological characteristics of diffuse large B-cell lymphoma involving small and large intestines: an analysis of 126 patients

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Abstract

We analyzed the clinicopathologic characteristics of 136 intestinal diffuse large B-cell lymphomas (DLBCLs) among 126 patients. The DLBCL sites were categorized as: duodenum (n = 23), ileocecal region (n = 63), other small intestine (n = 29), rectum (n = 7), and other large intestine (n = 14). Patients with DLBCLs of the ileocecal region or other small intestine frequently underwent surgery for ileus or perforations (P < 0.001), were predominantly male (P = 0.042), and had a higher incidence of limited-stage disease (P = 0.001), lower International Prognostic Index (P = 0.015), and lower incidence of lactate dehydrogenase elevation (P = 0.007) than those with DLBCLs of other regions. Half of the intestinal DLBCLs exhibited the germinal center B-cell phenotype. A low-grade B-cell lymphoma background was found in 21% of the cases; the prevalence was significantly lower in the ileocecal region (13%, P = 0.025), suggesting a higher incidence of de novo DLBCLs. Intestinal follicular lymphoma (FL) and mucosa-associated lymphoid tissue (MALT) lymphoma backgrounds were observed in 10% and 0% of the cases, respectively. Five percent (5/107) of intestinal DLBCL cases were Epstein–Barr virus-encoded RNA-1 positive. The clinicopathologic characteristics of the DLBCLs differed by region. Histologic transformation of intestinal FL was observed in around 10% of the intestinal DLBCL cases.

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Acknowledgements

We would like to thank Ms. Miura, Ms. Kina, and Ms. Sakaguchi for their technical assistance.

Funding

This work was supported in part by the Japan Agency for Medical Research and Development Fund (18ck0106349h0002)

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Authors and Affiliations

  1. Pathology Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan

    Akiko Miyagi Maeshima & Hirokazu Taniguchi

  2. Department of Hematology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan

    Yuta Ito, Shunsuke Hatta, Tomotaka Suzuki, Sayako Yuda, Shinichi Makita, Suguru Fukuhara, Wataru Munakata, Tatsuya Suzuki, Dai Maruyama & Koji Izutsu

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  1. Akiko Miyagi Maeshima
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  2. Hirokazu Taniguchi
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Correspondence to Akiko Miyagi Maeshima.

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Maeshima, A.M., Taniguchi, H., Ito, Y. et al. Clinicopathological characteristics of diffuse large B-cell lymphoma involving small and large intestines: an analysis of 126 patients. Int J Hematol 110, 340–346 (2019). https://doi.org/10.1007/s12185-019-02687-x

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  • DOI: https://doi.org/10.1007/s12185-019-02687-x

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