International Journal of Hematology

, Volume 107, Issue 6, pp 709–711 | Cite as

10-year complete remission in a Philadelphia chromosome-positive acute lymphoblastic leukemia patient using imatinib without high-intensity chemotherapy or allogeneic stem cell transplantation

  • Katsumichi Fujimaki
  • Yukako Hattori
  • Hideaki Nakajima
Case Report


The outcome of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph-ALL) has improved with the use of tyrosine kinase inhibitors, such as imatinib and dasatinib. We report a 63-year-old woman with Ph-ALL who maintained complete remission for 10 years using imatinib without high-intensity chemotherapy or allogeneic stem cell transplantation. She underwent induction therapy with imatinib plus prednisolone and achieved complete remission by day 53. Imatinib was continued until 103 months, when it was stopped in response to renal dysfunction; however, the patient continued to exhibit molecular remission at 120 months. This is the first report in the literature describing a patient with Ph-ALL who achieved remission for more than 10 years after treatment only with imatinib.


Philadelphia chromosome Acute lymphoblastic leukemia Imatinib Complete remission 


Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest.


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Copyright information

© The Japanese Society of Hematology 2017

Authors and Affiliations

  1. 1.Department of HematologyFujisawa City HospitalFujisawaJapan
  2. 2.Department of Hematology and Clinical ImmunologyYokohama City University School of MedicineYokohamaJapan

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