International Journal of Hematology

, Volume 107, Issue 4, pp 451–459 | Cite as

A new prognostic score comprising lactate dehydrogenase, albumin and neutrophil to lymphocyte ratio to predict sensitivity to first-line chemotherapy in patients with peripheral T-cell lymphomas

  • Satoshi Kaito
  • Yusuke Kanemasa
  • Yuki Sasaki
  • Toshihiro Okuya
  • Tsukasa Yamaguchi
  • Chikako Funasaka
  • Tatsu Shimoyama
  • Yasushi Omuro
  • Tsunekazu Hishima
  • Yoshiharu Maeda
Original Article


No standard therapy for peripheral T-cell lymphomas (PTCLs) has been established, and treatment outcomes are poor. Upfront stem cell transplantation has been investigated in several studies, some of which have reported promising outcomes. However, some patients maintain long-term remission after chemotherapy alone. It is thus important to predict sensitivity to first-line chemotherapy to optimize treatment strategies. In the present study, we retrospectively analyzed time to treatment failure (TTF) of first-line chemotherapy in 59 patients with PTCLs. On multivariate analysis for TTF, elevated lactate dehydrogenase level, hypoalbuminemia, and high neutrophil-to-lymphocyte ratio were significant prognostic factors. Using these three factors, we also developed a new model that effectively distinguished patient outcomes. The TTF rate at 1 year from diagnosis was 71.4% in patients with score 0 (0 factor), 31.8% with score 1 (1 factor) and 4.5% with score 2 (2–3 factors) (P < 0.001). The prognostic power was superior to that of the Prognostic Index for PTCL-unspecified score. Patients with scores of 1 and 2 had poor TTF, and may be candidates for upfront stem cell transplantation if they respond to first-line chemotherapy. Further investigation in a larger cohort is warranted to determine the general applicability of this score.


Peripheral T-cell lymphomas (PTCLs) First-line chemotherapy Lactate dehydrogenase (LDH) Albumin Neutrophil to lymphocyte ratio (NLR) 



We would like to thank all the patients who took part in this study.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interests.


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Copyright information

© The Japanese Society of Hematology 2017

Authors and Affiliations

  • Satoshi Kaito
    • 1
  • Yusuke Kanemasa
    • 1
  • Yuki Sasaki
    • 2
  • Toshihiro Okuya
    • 1
  • Tsukasa Yamaguchi
    • 1
  • Chikako Funasaka
    • 1
  • Tatsu Shimoyama
    • 1
  • Yasushi Omuro
    • 1
  • Tsunekazu Hishima
    • 3
  • Yoshiharu Maeda
    • 1
  1. 1.Department of Medical OncologyTokyo Metropolitan Cancer and Infectious Diseases Center Komagome HospitalTokyoJapan
  2. 2.Department of Clinical Research SupportTokyo Metropolitan Cancer and Infectious Diseases Center Komagome HospitalTokyoJapan
  3. 3.Department of PathologyTokyo Metropolitan Cancer and Infectious Diseases Center Komagome HospitalTokyoJapan

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