The prognostic significance of 13q deletions of different sizes in patients with B-cell chronic lymphoproliferative disorders: a retrospective study

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Patients with chronic lymphocytic leukemia (CLL) with 13q deletion as the sole cytogenetic abnormality usually have a favorable outcome, but the frequency of the 13q14 deletion and its impact on the outcome of other B-cell chronic lymphoproliferative disorders (BCLPDs) remain unclear. To further characterize this aberration, we investigated the prognostic significance of 13q deletion in 541 patients with BCLPDs. We performed fluorescence in situ hybridization (FISH) studies with 13q locus-specific LSI-D13S25 and LSI-RB1 probes. 52.1% of the patients with CLL harbored 13q deletion, which was significantly higher than that of other BCLPDs (p < 0.001). The size of 13q deletion was heterogeneous in both CLL and other BCLPDs. However, the distribution of cases with different deletion sizes showed no significant difference between the two groups. Whereas 13q deletion was a favorable prognostic factor in CLL, a large deletion of 13q was associated with poor prognosis in terms of time to first therapy (p = 0.020), progression-free survival (p = 0.05) and overall survival (p = 0.002) in BCLPD cases other than CLL. In conclusion, the deletion of 13q varied in size both in CLL and in other BCLPDs and adversely influenced the prognosis of patients with other BCLPDs.

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B-cell chronic lymphoproliferative disorders


Interphase fluorescence in situ hybridization


Chronic lymphocytic leukemia


Time to first therapy


Progression-free survival


Overall survival


Spleen marginal zone lymphoma


Hairy cell lymphoma


Waldenström macroglobulinemia


Mucosa-associated lymphoid tissue lymphoma


Bone marrow involvement


Nodal marginal zone lymphoma


Follicular lymphoma


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This publication was funded by the Chinese Academy of Medical Sciences and Peking Union Medical College.

Author information




Data collection was by SY, HL, WX, HL, SZ, WL, RL. SY, HL, CL, YX, GA, HW, KR performed analyses. SY, HL, ZL, ZY, DZ, LQ interpreted results of analyses. All authors prepared, reviewed and gave critical input into each stage of the manuscript.

Corresponding authors

Correspondence to Zengjun Li or Lugui Qiu.

Ethics declarations

Ethics approval and consent to participate

This study was approved by the Ethics Review Boards of Institute of Hematology and Blood Disease Hospital due to its retrospective character.

Consent for publication

Not applicable.

Availability of data and materials

Data are available on request from the authors, due to the fact that they contain treatment-specific information they may not be uploaded on a public shared base.


This work is supported by grants from the National Science and Technology Supporting Program (2014BAI09B12), the National Natural Science Foundation of China (81370632 and 81400092), the Fundamental Application and Advanced Technology Research Program of Tianjin (15JCYBJC27900).

Conflict of interest

The authors declare no competing financial interests.

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Yi, S., Li, H., Li, Z. et al. The prognostic significance of 13q deletions of different sizes in patients with B-cell chronic lymphoproliferative disorders: a retrospective study. Int J Hematol 106, 418–425 (2017).

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  • 13q14 deletion
  • BCLPDs
  • Interphase fish
  • Prognosis