International Journal of Hematology

, Volume 105, Issue 4, pp 532–535 | Cite as

Dabigatran overdose: a case report of acute hepatitis. Extracorporeal treatment

  • Mariagrazia Porru
  • Antonella MameliEmail author
  • Maria E. Cianchetti
  • Mario Musu
  • Paola Schirru
  • Maria F. Ruberto
  • Doris Barcellona
  • Francesco Marongiu
Case Report


Dabigatran is an oral, direct thrombin inhibitor approved by international regulatory agencies for stroke prevention in patients with paroxysmal or persistent non-rheumatic atrial fibrillation (AF). The benefits of dabigatran are widely described, but its use in the geriatric population is not without risk. Chronic kidney disease is a common comorbidity with AF, and thus frequent checks of renal function in elderly patients are recommended. We report a case of dabigatran intoxication in an elderly man affected by heart failure and worsening renal function, who developed acute hepatitis and coma, which was successfully treated with continuous veno-venous hemodiafiltration. Although extracorporeal therapy has been suggested as a strategy for clearing dabigatran during acute bleeding, this approach may be useful in other dabigatran-related, life-threatening conditions, such as that described in this report.


Dabigatran etexilate Acute hepatitis Overdose Continuous veno-venous hemodiafiltration 



We thank Mr. Barry Mark Wheaton for his editing assistance.


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Copyright information

© The Japanese Society of Hematology 2016

Authors and Affiliations

  • Mariagrazia Porru
    • 1
  • Antonella Mameli
    • 1
    Email author
  • Maria E. Cianchetti
    • 1
  • Mario Musu
    • 2
  • Paola Schirru
    • 1
  • Maria F. Ruberto
    • 1
  • Doris Barcellona
    • 1
  • Francesco Marongiu
    • 1
  1. 1.Internal Medicine and Haemocoagulopathies UnitAzienda Ospedaliero Universitaria (A.O.U.), Presidio “Duilio Casula”, University of CagliariMonserratoItaly
  2. 2.Intensive Care UnitAzienda Ospedaliero Universitaria (A.O.U.), Presidio “Duilio Casula”, University of CagliariMonserratoItaly

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