Abstract
Primary bone lymphomas comprise <1 % of all malignant lymphomas, and there have been only a limited number of reports on primary adult T-cell leukemia/lymphoma (ATLL) of bone. Here, we report two cases of primary ATLL of bone. The first case was a 41-year-old woman with multiple bone tumors. She was diagnosed with ATLL of the skull through biopsy and treated with chemotherapy. Although the bone lesions showed transient improvement, the subsequent central nervous system (CNS) invasion of ATLL occurred and she died 7 months after diagnosis. The second case was a 65-year-old man with right coxodynia. He was diagnosed with ATLL through right femoral biopsy, and the lesion improved with chemotherapy. However, CNS invasion of ATLL developed during chemotherapy, and he died 10 months after diagnosis. Both the patients with primary ATLL of the bone reported here experienced CNS invasion. Thus, ATLL treatment should aim to prevent CNS invasion at an early stage.
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Uchiyama T, Yodoi J, Sagawa K, Takatsuki K, Uchino H. Adult T-cell leukemia: clinical and hematologic features of 16 cases. Blood. 1977;50:481–92.
Poiesz BJ, Ruscetti FW, Gazdar AF, Bunn PA, Minna JD, Gallo RC. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci USA. 1980;77:7415–9.
Shimoyama M. Diagnostic criteria and classification of clinical subtypes of adult T-cell leukemia-lymphoma. A report from the Lymphoma Study Group (1984–87). Brit J Haematol. 1991;79:428–37.
Tsukasaki K, Utsunomiya A, Fukuda H, Shibata T, Fukushima T, Takatsuka Y, et al. VCAP-AMP-VECP compared with biweekly CHOP for adult T-cell leukemia-lymphoma: Japan Clinical Oncology Group Study JCOG9801. J Clin Oncol. 2007;25:5458–64.
Tsukasaki K, Hermine O, Bazarbachi A, Ratner L, Ramos JC, Harrington W Jr, et al. Definition, prognostic factors, treatment, and response criteria of adult T-cell leukemia-lymphoma: a proposal from an international consensus meeting. J Clin Oncol. 2009;27:453–9.
Desai S, Jambhekar NA, Soman CS, Advani SH. Primary lymphoma of bone: a clinicopathologic study of 25 cases reported over 10 years. J Surg Oncol. 1991;46:265–9.
Gianelli U, Patriarca C, Moro A, Ponzoni M, Giardini R, Massimino M, et al. Lymphomas of the bone: a pathological and clinical study of 54 cases. Int J Surg Pathol. 2002;10:257–66.
Matikas A, Briasoulis A, Tzannou I, Oikonomopoulou D, Bakiri M, Karmiris T, et al. Primary bone lymphoma: a retrospective analysis of 22 patients treated in a single tertiary center. Acta Haematol. 2013;130:291–6.
Heyning FH, Hogendoorn PC, Kramer MH, Hermans J, Kluin-Nelemans JC, Noordijk EM, et al. Primary non-Hodgkin’s lymphoma of bone: a clinicopathological investigation of 60 cases. Leukemia. 1999;13:2094–8.
Takemoto S, Matsuoka M, Sakata K, Matsuzaki H, Akagi K, Yamaguchi K, et al. Primary adult T cell leukemia of bone: two patients with primary bone lesion showing monoclonal integration of HTLV-I proviral DNA. Leukemia. 1996;10:333–7.
Hara T, Wakatsuki S, Ozaki S, Abe M, Kosaka M. Primary adult T-cell leukemia/lymphoma of bone. Int J Hematol. 2004;79:157–60.
Martin A, Conde E, Arnan M, Canales MA, Deben G, Sancho JM, et al. R-ESHAP as salvage therapy for patients with relapsed or refractory diffuse large B-cell lymphoma: the influence of prior exposure to rituximab on outcome. A GEL/TAMO study. Haematologica. 2008;93:1829–36.
Nosaka K, Miyamoto T, Sakai T, Mitsuya H, Suda T, Matsuoka M. Mechanism of hypercalcemia in adult T-cell leukemia: overexpression of receptor activator of nuclear factor kappaB ligand on adult T-cell leukemia cells. Blood. 2002;99:634–40.
Tabata M, Takahashi H, Izumi T, Komatsu N, Tsunoda J, Yoshida M, et al. Adult T cell leukemia lymphoma (ATL) localized in the right tibial bone. Leuk Lymphoma. 1999;35:189–92.
Yamada Y, Tomonaga M, Fukuda H, Hanada S, Utsunomiya A, Tara M, et al. A new G-CSF-supported combination chemotherapy, LSG15, for adult T-cell leukemia-lymphoma: Japan Clinical Oncology Group Study 9303. Brit J Haematol. 2001;113:375–82.
Govi S, Christie D, Messina C, Bruno Ventre M, Gracia Medina EA, Porter D, et al. The clinical features, management and prognostic effects of pathological fractures in a multicenter series of 373 patients with diffuse large B-cell lymphoma of the bone. Ann Oncol. 2014;25:176–81.
Messina C, Ferreri A, Govi S, Bruno-Ventre M, Gracia Medina EA, Porter D, et al. Clinical features, management and prognosis of multifocal primary bone lymphoma: a retrospective study of the international extranodal lymphoma study group (the IELSG 14 study). Brit J Haematol. 2014;164:834–40.
Fukushima T, Taguchi J, Moriuchi Y, Yoshida S, Itonaga H, Ando K, et al. Allogeneic hematopoietic stem cell transplantation for ATL with central nervous system involvement: the Nagasaki transplant group experience. Int J Hematol. 2011;94:390–4.
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Kuriyama, T., Kawano, N., Yamashita, K. et al. Two cases of primary adult T-cell leukemia/lymphoma of bone: case reports and a review of the literature. Int J Hematol 104, 392–395 (2016). https://doi.org/10.1007/s12185-016-2015-1
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DOI: https://doi.org/10.1007/s12185-016-2015-1