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Combined prognostic value of absolute lymphocyte/monocyte ratio in peripheral blood and interim PET/CT results in Hodgkin lymphoma

International Journal of Hematology volume 103, pages 63–69 (2016)Cite this article

Abstract

Decreased absolute lymphocyte/monocyte ratio (LMR) in peripheral blood has been reported as an unfavorable prognostic marker in Hodgkin lymphoma. We aimed to investigate whether combining LMR and interim PET/CT scan result (PET2) confers stronger prognostic value than PET2 alone. 121 HL patients were investigated. LMR was calculated from a blood sample taken at the time of diagnosis. PET2 was carried out after the second chemotherapy cycle. Survival was calculated using the Kaplan–Meier method and significance was determined by log-rank test. Effect of variants on survival results was examined using univariate and multivariate analyses. Best LMR cut-off value was determined by receiver operating characteristic (ROC) curve. Best LMR cut-off value was 2.11 in the case of our patients (LMR >2.11: favorable, LMR ≤2.11: unfavorable). Overall and progression-free survivals (OS/PFS) were significantly worse both in lower LMR (≤2.11) (OS: P = 0.041, PFS: P = 0.044) and PET2 positive groups (OS: P < 0.001, PFS: P < 0.001). In PET2 positive patient group (n = 32) the low LMR result meant a significantly worse OS (0.030) and PFS (0.001). Both LMR and PET2 proved to be independent prognostic factors on multivariate analysis, and strengthened each other’s effect.

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Acknowledgments

The authors would like to acknowledge Katalin Hodosi for her support in the statistical analysis.

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Affiliations

  1. Department of Hematology, Institute of Internal Medicine, University of Debrecen, Nagyerdei krt. 98, 4032, Debrecen, Hungary

    Zsofia Simon, Z. Miltenyi, K. Husi, F. Magyari, A. Jona & A. Illes

  2. Scanomed Ltd., Budapest, Hungary

    S. Barna & I. Garai

  3. MISEK, Miskolc, Hungary

    Z. Nagy

  4. Hetenyi Geza Hospital, Szolnok, Hungary

    G. Ujj

  5. Josa Andras Hospital, Nyiregyhaza, Hungary

    L. Szerafin

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  1. Zsofia Simon
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  2. S. Barna
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  3. Z. Miltenyi
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  4. K. Husi
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  5. F. Magyari
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  6. A. Jona
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  7. I. Garai
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  8. Z. Nagy
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  9. G. Ujj
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  10. L. Szerafin
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  11. A. Illes
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Correspondence to Zsofia Simon.

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Simon, Z., Barna, S., Miltenyi, Z. et al. Combined prognostic value of absolute lymphocyte/monocyte ratio in peripheral blood and interim PET/CT results in Hodgkin lymphoma. Int J Hematol 103, 63–69 (2016). https://doi.org/10.1007/s12185-015-1884-z

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  • DOI: https://doi.org/10.1007/s12185-015-1884-z

Keywords

  • Hodgkin lymphoma
  • Prognostic marker
  • Interim PET/CT
  • Lymphocyte/monocyte ratio