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A case of clonally distinct relapse of Burkitt lymphoma 9 years after complete remission

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Abstract

We report a case of HIV-negative Burkitt lymphoma (BL) that relapsed 9 years after complete remission. We performed a polymerase chain reaction analysis of three regions of the VDJ junction of the immunoglobulin heavy chain (IGH) gene and compared the clonality of the first and second BL lesions, which were found to be clonally distinct. The patient received the R-Hyper CVAD/R-MA regimen; however, leukoencephalopathy subsequently developed due to the effect of cytarabine, and the regimen was changed to R-IVAM. The patient achieved complete remission and received high-dose chemotherapy following autologous stem cell transplantation. He maintained the complete remission for 72 months after transplantation. Given this outcome, we suggest that clonally distinct relapse of HIV-negative BL may exhibit a good prognosis.

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Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Division of Hematology/Oncology, Department of Internal Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1143, Japan

    Minoru Kojima, Hiromichi Murayama, Makiko Moriuchi, Yoshiaki Ogawa & Kiyoshi Ando

  2. Department of Pathology, Tokai University School of Medicine, Isehara, Japan

    Naoya Nakamura, Mami Tokunaka, Yara Yukie Kikuti & Tomoki Kikuchi

  3. Department of Cell Transplantation and Regenerative Medicine, Tokai University School of Medicine, Isehara, Japan

    Miharu Yabe

  4. Department of Internal Medicine, Nagaoka Chuo General Hospital, Niigata, Japan

    Kosuke Tsuboi

Authors
  1. Minoru Kojima
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  2. Naoya Nakamura
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  3. Miharu Yabe
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  4. Mami Tokunaka
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  5. Yara Yukie Kikuti
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  6. Tomoki Kikuchi
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  7. Hiromichi Murayama
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  8. Makiko Moriuchi
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  9. Kosuke Tsuboi
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  10. Yoshiaki Ogawa
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  11. Kiyoshi Ando
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Corresponding author

Correspondence to Minoru Kojima.

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Kojima, M., Nakamura, N., Yabe, M. et al. A case of clonally distinct relapse of Burkitt lymphoma 9 years after complete remission. Int J Hematol 101, 520–524 (2015). https://doi.org/10.1007/s12185-014-1729-1

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  • DOI: https://doi.org/10.1007/s12185-014-1729-1

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