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Hepcidin and GDF15 in anemia of multiple myeloma

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Abstract

Multiple myeloma (MM) is a malignant disease of plasma cells and is often accompanied by anemia which may influence its progression and survival. The mechanism of anemia of chronic disease (ACD) in which iron homeostasis is impaired underlies that of MM-related anemia. In this study, we analyzed the role of hepcidin which is the main mediator of ACD and ACD-related cytokines in peripheral blood of MM patients. We showed that HAMP mRNA and growth differentiation factors 15 (GDF15) mRNA expressions in peripheral blood mononuclear cells (PBMCs) and plasma hepcidin, GDF15, interleukin-6 and erythropoietin in MM patients all increased significantly as compared to those in controls. In MM patients, the expression of HAMP mRNA showed a positive correlation with serum ferritin level, and a negative correlation with hemoglobin level. The levels of plasma hepcidin and GDF15 were significantly decreased in MM patients who achieved complete remission after six cycles VD (bortezomib + dexamethasone) regimen chemotherapy. These data indicated that overexpression of HAMP mRNA in PBMCs significantly correlated with increased plasma hepcidin level and may be involved in the pathogenesis of MM-related anemia. Furthermore, the levels of plasma hepcidin and GDF15 may be valuable in assessing the progress of MM.

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Acknowledgments

This project was supported by the anticancer major special project of Tianjin (12ZCDZSY17900, 12ZCDZSY18000) and Medical Association of Multiple Myeloma Foundation Project (20090901).

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Authors and Affiliations

  1. Department of Hematology, General Hospital, Tianjin Medical University, 154 Anshandao, Heping District, Tianjin, 300052, People’s Republic of China

    Shuchong Mei, Huaquan Wang, Rong Fu, Wen Qu, Limin Xing, Guojin Wang, Jia Song, Hong Liu, Lijuan Li, Xiaoming Wang, Yuhong Wu, Jin Guan, Erbao Ruan & Zonghong Shao

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  1. Shuchong Mei
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  2. Huaquan Wang
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  3. Rong Fu
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  4. Wen Qu
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  5. Limin Xing
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  6. Guojin Wang
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  7. Jia Song
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  8. Hong Liu
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  9. Lijuan Li
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  10. Xiaoming Wang
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  11. Yuhong Wu
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  12. Jin Guan
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  13. Erbao Ruan
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  14. Zonghong Shao
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Correspondence to Zonghong Shao.

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Mei, S., Wang, H., Fu, R. et al. Hepcidin and GDF15 in anemia of multiple myeloma. Int J Hematol 100, 266–273 (2014). https://doi.org/10.1007/s12185-014-1626-7

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  • DOI: https://doi.org/10.1007/s12185-014-1626-7

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