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Acute myeloid leukemia and colon carcinoma during the course of acromegaly

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Abstract

We describe the case of a 70-year-old male with acromegaly who developed colon carcinoma and myelodysplastic syndrome (MDS) during the course of acromegaly. MDS progressed to acute myeloid leukemia, but was refractory to chemotherapy. Acromegaly is a rare disorder caused by excessive amounts of growth hormone (GH) primarily secreted by pituitary adenomas. Patients with acromegaly are more prone to develop various malignancies, but there are few reports of hematological malignancies in such patients. In the present case, excessive endogenous GH and insulin-like growth factor-I levels may have altered cell proliferation and thereby affected the oncogenesis and chemosensitivity of both malignancies.

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Acknowledgments

The authors would like to thank Enago (http://www.enago.jp) for English editing services.

Conflict of interest

The authors declare no conflict of interest.

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Authors and Affiliations

  1. Department of Hematology and Oncology, Konan Kosei Hospital, 137 Oomatsubara, Takaya-cho, Konan-city, Aichi, 483-8704, Japan

    Kazutaka Ozeki, Yoshihisa Morishita, Koji Umemura, Yohei Yamaguchi, Shotaro Tatekawa, Koichi Watamoto & Akio Kohno

  2. Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan

    Sigeki Saito

  3. Department of Endocrinology, Konan Kosei Hospital, Konan, Japan

    Tsuyoshi Nogimori

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  1. Kazutaka Ozeki
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  2. Yoshihisa Morishita
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Correspondence to Kazutaka Ozeki.

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Ozeki, K., Morishita, Y., Saito, S. et al. Acute myeloid leukemia and colon carcinoma during the course of acromegaly. Int J Hematol 98, 620–624 (2013). https://doi.org/10.1007/s12185-013-1431-8

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  • DOI: https://doi.org/10.1007/s12185-013-1431-8

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