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Mesenchymal stromal cells for cell therapy: besides supporting hematopoiesis

International Journal of Hematology volume 95, pages 34–46 (2012)Cite this article

Abstract

Mesenchymal stromal cells (MSC) have attracted the attention of scientists and clinicians due to their self-renewal, capacity for multipotent differentiation, and immunomodulatory properties. Some essential problems remain to be solved before the clinical application of MSC. Platelet lysate (PL) has recently been used as a substitute for FBS in MSC amplification in vitro to achieve clinically applicable numbers of MSC. In addition to promising trials in regenerative medicine, such as in the treatment of major bone defects and myocardial infarction, MSC have shown therapeutic effect other than direct hematopoiesis support in hematopoietic reconstruction. It has been confirmed that MSC promote hematopoietic cell engraftment and immune recovery after allogeneic hematopoietic stem cell transplantation, probably through the provision of cytokines, matrix proteins, and cell-to-cell contacts. Their suppressive effects on immune cells, including T cells, B cells, NK cells and DC cells, suggest MSCs as a novel therapy for GVHD and other autoimmune disorders. These cells thus present as promising candidates for cellular therapy in the fields of regenerative medicine, allogeneic hematopoietic stem cell transplantation, and autoimmune disorders.

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Acknowledgments

This work was partially supported by the National Natural Science Foundation, China (30828007), the Key Projects of Natural Science Foundation of Chongqing (SCTC, 2007BA5011).

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Affiliations

  1. Department of Internal Medicine, No. 324 Hospital of PLA, Chongqing, 400020, China

    Lei Hao

  2. Institute of Combined Injury, State Key Laboratory of Trauma, Burn and Combined Injury, Third Military Medical University, Chongqing, 400038, China

    Huiqin Sun & Tao Wang

  3. Department of Hematology, Daping Hospital, Chongqing, 400038, China

    Jin Wang

  4. Department of Chemical Defense and Toxicology, Institute of Toxicology, School of Preventive Medicine, Third Military Medical University, Chongqing, 400038, China

    Mingke Wang & Zhongmin Zou

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  1. Lei Hao
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  2. Huiqin Sun
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  3. Jin Wang
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  4. Tao Wang
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  5. Mingke Wang
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  6. Zhongmin Zou
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Correspondence to Zhongmin Zou.

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Hao, L., Sun, H., Wang, J. et al. Mesenchymal stromal cells for cell therapy: besides supporting hematopoiesis. Int J Hematol 95, 34–46 (2012). https://doi.org/10.1007/s12185-011-0991-8

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  • DOI: https://doi.org/10.1007/s12185-011-0991-8

Keywords

  • Mesenchymal stromal cells
  • Regenerative medicine
  • Immunomodulatory effect
  • GVHD
  • Cell expansion in vitro