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TCL1A gene involvement in T-cell prolymphocytic leukemia in Japanese patients

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Abstract

T-cell prolymphocytic leukemia (T-PLL) is a rare type of peripheral T-cell leukemia. In this study, we examined the clinical and biological characteristics of 11 Japanese patients with T-PLL. Median age was 74 years, with male predominance. Median lymphocyte frequency was 85.3% in blood. Physical characteristics were splenomegaly (36.4%), tiny lymph adenopathy (63.6%), skin lesion (9.1%) and pleural effusion (27.3%). Median survival was 30.1 months, despite treatment with various chemotherapeutic modalities. Although complex chromosomal abnormalities were observed in 5 of 11 cases (45.5%), typical 14q32 and Xq28 abnormalities were not detected. TCL1A mRNA expression was observed in 6 of 11 cases (54.5%) on real-time quantitative PCR. In 5 of these 6 cases, flow cytometric analysis and/or immunohistochemistry confirmed the expression of TCLA1 protein. Split signals for the TCL1 region on fluorescence in situ hybridization confirmed rearrangement in 3 out of 7 cases evaluated. These cases corresponded to cases that were positive for TCL1A expression, suggesting that rearrangement of the TCL1 region induced high expression of TCL1A gene. In summary, a substantial number of T-PLL cases in Japan had abnormal expression of TCL1A, probably due to rearrangement of TCL1 region. Expression and/or rearrangement of TCL1A may, therefore, be a useful marker for diagnosing T-PLL, regardless of chromosomal abnormalities.

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Acknowledgments

We are grateful to professor Masayuki Noguchi (Hokkaido University), who kindly provided experimental materials.

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Authors and Affiliations

  1. Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan

    Akihiko Yokohama, Akio Saitoh, Hirotaka Nakahashi, Takeki Mitsui, Hiromi Koiso, Hideki Uchiumi, Takayuki Saitoh, Hiroshi Handa & Yoshihisa Nojima

  2. Blood Transfusion Service, Faculty of Medicine, University Hospital, Gunma University, 3-39-15 Showa, Maebashi, Gunma, 371-8511, Japan

    Akihiko Yokohama & Masamitsu Karasawa

  3. Department of Internal Medicine, Fukaya Red Cross Hosiptal, Fukaya, Saitama, Japan

    Yoshitora Kim

  4. Department of Internal Medicine, Fujioka General Hospital, Fujioka, Gunma, Japan

    Takahiro Jimbo

  5. Department of Hematology, Gunma Prefectural Cancer Center, Ota, Gunma, Japan

    Kayoko Murayama

  6. Leukemia Research Center, Saiseikai Maebashi Hospital, Maebashi, Gunma, Japan

    Tohru Sakura

  7. School of Health Science, Faculty of Medicine, Gunma University, Maebashi, Japan

    Hirokazu Murakami

  8. Oncology Center, Faculty of Medicine, University Hospital, Gunma University, Maebashi, Japan

    Norifumi Tsukamoto

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  1. Akihiko Yokohama
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  2. Akio Saitoh
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  9. Hiroshi Handa
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  11. Kayoko Murayama
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  14. Masamitsu Karasawa
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  15. Yoshihisa Nojima
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Correspondence to Akihiko Yokohama.

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Yokohama, A., Saitoh, A., Nakahashi, H. et al. TCL1A gene involvement in T-cell prolymphocytic leukemia in Japanese patients. Int J Hematol 95, 77–85 (2012). https://doi.org/10.1007/s12185-011-0986-5

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  • DOI: https://doi.org/10.1007/s12185-011-0986-5

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