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Heart rate variability during and after peripheral blood stem cell leukapheresis in autologous transplant patients and allogeneic transplant donors

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Abstract

Side effects of varying severity are frequent in peripheral blood stem cell harvest (PBSCH). Life-threatening complications associated with PBSCH have also been reported. Heart rate variability (HRV), which reflects sympathovagal balance and autonomic cardiovascular control, has been a subject of intense interest in various diseases precipitating sudden death. Here, we prospectively assessed the impact of leukapheresis on HRV among autologous hematopoietic cell transplant patients and healthy donors. We found that HRV indicators, the standard deviation of normal-to-normal intervals (SDNN) value, the square root of the mean of the sum of squared differences between the adjacent normal-to-normal interval (r-MSSD) value, total frequency (TF), high frequency (HF) and low frequency (LF) powers decreased significantly to morbid levels during leukapheresis (all P < 0.01). Morbid changes in SDNN value, TF and LF powers were significantly sustained for 6–9 h after leukapheresis (all P < 0.05). Furthermore, TF and LF powers prior to leukapheresis were significantly lower in subjects with symptomatic hypotension than in the other subjects [3282 (3121–4427) vs. 6018 (4983–9816) ms2, P = 0.03; 93 (42–144) vs. 237 (142–360) ms2, P = 0.03, respectively]. Our results suggest that HRV analysis might be of use in evaluating and predicting the adverse effects of cardiovascular complications in PBSCH.

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Acknowledgments

This work was supported by a Grant-in-Aid for Scientific Research from the Japanese Ministry of Education, Science, Sports and Culture, and a grant from the Japanese Ministry of Health, Welfare and Labor.

Conflict of interest statement

All the authors declare no conflict of interest.

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Authors and Affiliations

  1. Hematology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan

    Takahiko Nakane, Hirohisa Nakamae, Hideo Koh, Mika Nakamae, Ran Aimoto, Yoshiki Terada, Ki-Ryang Koh, Takahisa Yamane & Masayuki Hino

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  1. Takahiko Nakane
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  2. Hirohisa Nakamae
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  3. Hideo Koh
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  4. Mika Nakamae
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  5. Ran Aimoto
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  6. Yoshiki Terada
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  7. Ki-Ryang Koh
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  8. Takahisa Yamane
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  9. Masayuki Hino
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Correspondence to Hirohisa Nakamae.

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Nakane, T., Nakamae, H., Koh, H. et al. Heart rate variability during and after peripheral blood stem cell leukapheresis in autologous transplant patients and allogeneic transplant donors. Int J Hematol 91, 478–484 (2010). https://doi.org/10.1007/s12185-010-0543-7

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  • DOI: https://doi.org/10.1007/s12185-010-0543-7

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