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Blimp-1 is a tumor suppressor gene in lymphoid malignancies

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Abstract

B lymphocyte-induced maturation protein (Blimp-1) is a transcriptional factor, which controls the terminal differentiation of mature B cells to plasma cells. Blimp-1 is also called positive regulatory domain I-binding factor-1 (PRDI-BF1) or PR (PRDI-BF1-RIZ) domain zinc finger protein 1 (PRDM1). Furthermore, Blimp-1 is located in chromosome 6q21-22.1, a region frequently deleted in several tumors including lymphoid malignancies and has been supposed to be a candidate of tumor suppressor gene. Recently, mutational inactivation of Blimp-1 has been identified in a subset of diffuse large B-cell lymphomas of the activated B-cell type. In addition, an important role for Blimp-1 in maintaining the homeostasis of effector T cells is emerging and high expression of Blimp-1β, a splicing variant of Blimp-1, have been presumed to be associated with poor prognosis in T cell lymphoma although this aspect of the gene needs further investigation. For this reason, we focused on the tumor suppressor function of Blimp-1 on not only B but also T cell malignancies in this review.

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Authors and Affiliations

  1. Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Akira Hangaishi & Mineo Kurokawa

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  1. Akira Hangaishi
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  2. Mineo Kurokawa
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Correspondence to Mineo Kurokawa.

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Hangaishi, A., Kurokawa, M. Blimp-1 is a tumor suppressor gene in lymphoid malignancies. Int J Hematol 91, 46–53 (2010). https://doi.org/10.1007/s12185-009-0472-5

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  • DOI: https://doi.org/10.1007/s12185-009-0472-5

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