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Donor cell-derived acute lymphocytic leukemia after allogeneic stem cell transplantation for multiple myeloma

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Abstract

Donor cell leukemia (DCL) is a rare, but well-known, complication after allogeneic hematopoietic cell transplantation. We report a case of donor cell-derived acute lymphocytic leukemia (ALL) occurring in a 55-year-old man after allogeneic bone marrow transplantation (allo-BMT) from an HLA-matched unrelated donor for refractory multiple myeloma (MM). Molecular analysis using short tandem repeat sequences proved the ALL to be of donor origin. He underwent combination chemotherapy and second allo-BMT from an alternative donor. After second allo-BMT, extramedullary myeloma relapsed as tumor, but was successfully treated with proteasome inhibitor, bortezomib. However, he died from severe graft-versus-host disease four months after the second transplantation. Although more than 50 cases of DCL have been reported, there have been only two reports of DCL developed in MM patients including our case. This rare complication may give some insights into leukemogenesis.

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Authors and Affiliations

  1. Department of Internal Medicine, Niigata Cancer Center Hospital, 2-15-3 Kawagishi-cho, Chuou-ku, Niigata, Niigata, 951-8566, Japan

    Natsue Igarashi, Takaaki Chou, Takayuki Hirose, Yousuke Imai & Takuro Ishiguro

  2. Department of Pathology, Niigata Cancer Center Hospital, Niigata, Japan

    Keiichi Nemoto

Authors
  1. Natsue Igarashi
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  2. Takaaki Chou
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  3. Takayuki Hirose
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  4. Yousuke Imai
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  5. Takuro Ishiguro
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  6. Keiichi Nemoto
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Corresponding author

Correspondence to Natsue Igarashi.

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Igarashi, N., Chou, T., Hirose, T. et al. Donor cell-derived acute lymphocytic leukemia after allogeneic stem cell transplantation for multiple myeloma. Int J Hematol 90, 378–382 (2009). https://doi.org/10.1007/s12185-009-0397-z

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  • DOI: https://doi.org/10.1007/s12185-009-0397-z

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