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Immunoglobulin M ‘Flare’ after rituximab-associated acute tubular necrosis in Waldenström’s macroglobulinemia

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Abstract

Waldenström’s macroglobulinemia (WM) is a low-grade lymphoplasmacytic lymphoma characterized by a circulating monoclonal IgM. Renal involvement in classical cases of WM is rare, and the pathological hallmark finding in the renal biopsy specimen is a thrombotic microangiopathy. We report the case of a 69-year-old man with the diagnosis of WM for 3 months before he presented with acute renal failure (ARF). A renal biopsy performed suggested the diagnosis of acute tubular necrosis. The diagnosis of ARF related to IgM flare after Rituximab therapy was made.

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Authors and Affiliations

  1. Department of Nephrology, La Pitié-Salpêtrière Hospital, 47-80 Boulevard de l’Hôpital, Assistance Publique-Hôpitaux de Paris, Pierre et Marie Curie University, 75013, Paris, France

    Hassane Izzedine, Edward Bourry, Lucile Amrouche & Gilbert Deray

  2. Department of Pathology, Pitie-Salpetriere Hospital, Paris, France

    Isabelle Brocheriou & Frederique Capron

  3. Department of Clinical Hematology, Pitie-Salpetriere Hospital, Paris, France

    Madalina Uzunov & Veronique Leblond

Authors
  1. Hassane Izzedine
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  2. Edward Bourry
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  3. Lucile Amrouche
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  4. Isabelle Brocheriou
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  5. Madalina Uzunov
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  6. Frederique Capron
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  7. Veronique Leblond
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  8. Gilbert Deray
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Corresponding author

Correspondence to Hassane Izzedine.

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Izzedine, H., Bourry, E., Amrouche, L. et al. Immunoglobulin M ‘Flare’ after rituximab-associated acute tubular necrosis in Waldenström’s macroglobulinemia. Int J Hematol 89, 218–222 (2009). https://doi.org/10.1007/s12185-008-0244-7

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  • DOI: https://doi.org/10.1007/s12185-008-0244-7

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