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Correlation between characteristics of unrelated bone marrow donor and cell density of total nucleated cell in bone marrow harvest

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Abstract

The relationship between the features of bone marrow donor and the quality of marrow harvest has been unclear because most of bone marrow registries have multiple collection centers with somewhat different harvest procedures. We are able to address this issue for Tzu Chi General Hospital is the only collection center affiliated with Tzu Chi Taiwan Bone Marrow Registry. Between November 1997 and March 2002, data of 286 healthy unrelated donors was analyzed to correlate with the cell density of total nucleated cell in bone marrow harvests. The harvest procedure was standardized by single-hole harvest needle under general anesthesia. The operation staffs were restricted within the members of Oncology–Hematology division. The results showed that the cell density of bone marrow harvest was positively correlated with donor body weight and peripheral white blood cell count P = 0.0475, P < 0.0001, but negatively correlated with the total volume of bone marrow harvest P < 0.0001. We recommend that if multiple human leukocyte antigen-matched donors are available, donor with higher body weight and/or higher white blood cell count be selected for allogeneic bone marrow transplantation.

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References

  1. Storb R, Prentice RL, Thomas ED. Marrow transplantation for treatment of aplastic anemia. An analysis of factors associated with graft rejection. N Engl J Med. 1977;296(2):61–6.

    Article  CAS  PubMed  Google Scholar 

  2. Storb R, Prentice RL, Thomas ED, Appelbaum FR, Deeg HJ, Doney K, et al. Factors associated with graft rejection after HLA-identical marrow transplantation for aplastic anaemia. Br J Haematol. 1983;55(4):573–85. doi:10.1111/j.1365-2141.1983.tb02839.x.

    Article  CAS  PubMed  Google Scholar 

  3. Paulin T. Importance of bone marrow cell dose in bone marrow transplantation. Clin Transplant. 1992;6(1):48–54.

    CAS  PubMed  Google Scholar 

  4. Sierra J, Storer B, Hansen JA, Bjerke JW, Martin PJ, Petersdorf EW, et al. Transplantation of marrow cells from unrelated donors for treatment of high-risk acute leukemia: the effect of leukemic burden, donor HLA-matching, and marrow cell dose. Blood. 1997;89(11):4226–35.

    CAS  PubMed  Google Scholar 

  5. Barrett AJ, Ringden O, Zhang MJ, Bashey A, Cahn JY, Cairo MS, et al. Effect of nucleated marrow cell dose on relapse and survival in identical twin bone marrow transplants for leukemia. Blood. 2000;95(11):3323–7.

    CAS  PubMed  Google Scholar 

  6. Confer DL, Miller JP. Optimal donor selection: beyond HLA. Biology of blood and marrow transplantation. J Am Soc for Blood Marrow Transplant. 2007;13:83–6.

    Article  Google Scholar 

  7. Rocha V, Labopin M, Gluckman E, Powles R, Arcese W, Bacigalupo A, et al. Relevance of bone marrow cell dose on allogeneic transplantation outcomes for patients with acute myeloid leukemia in first complete remission: results of a European survey. J Clin Oncol. 2002;20(21):4324–30. doi:10.1200/JCO.2002.11.058.

    Article  PubMed  Google Scholar 

  8. Spitzer TR, Areman EM, Cirenza E, Yu M, Dickerson S, Kotula PL, et al. The impact of harvest center on quality of marrows collected from unrelated donors. J Hematother. 1994;3(1):65–70.

    Article  CAS  PubMed  Google Scholar 

  9. Kollman C, Howe CW, Anasetti C, Antin JH, Davies SM, Filipovich AH, et al. Donor characteristics as risk factors in recipients after transplantation of bone marrow from unrelated donors: the effect of donor age. Blood. 2001;98(7):2043–51. doi:10.1182/blood.V98.7.2043.

    Article  CAS  PubMed  Google Scholar 

  10. Ings SJ, Balsa C, Leverett D, Mackinnon S, Linch DC, Watts MJ. Peripheral blood stem cell yield in 400 normal donors mobilised with granulocyte colony-stimulating factor (G-CSF): impact of age, sex, donor weight and type of G-CSF used. Br J Haematol. 2006;134(5):517–25. doi:10.1111/j.1365-2141.2006.06223.x.

    Article  PubMed  Google Scholar 

  11. Vasu S, Leitman SF, Tisdale JF, Hsieh MM, Childs RW, Barrett AJ, et al. Donor demographic and laboratory predictors of allogeneic peripheral blood stem cell mobilization in an ethnically diverse population. Blood. 2008;112(5):2092–100. doi:10.1182/blood-2008-03-143677.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Wang TF, Wen SH, Chen RL, Lu CJ, Zheng YJ, Yang SH, et al. Factors associated with peripheral blood stem cell yield in volunteer donors mobilized with granulocyte colony-stimulating factors: the impact of donor characteristics and procedural settings. Biol Blood Marrow Transplant. 2008;14(11):1305–11. doi:10.1016/j.bbmt.2008.09.002.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Oncology-Hematology, Tzu Chi General Hospital, 707 Section 3 Chung Yang Road, Hualien, 970, Taiwan

    Ruey-Ho Kao, Chi-Cheng Li, Tso-Fu Wang, Sung-Chao Chu, Chao-Yuan Yao, Kuan-Po Huang & Yi-Feng Wu

  2. Department of Oncology, Tzu Chi University, Hualien, Taiwan

    Ruey-Ho Kao & Chi-Cheng Li

  3. Department of Public Health, Tzu Chi University, Hualien, Taiwan

    Cheng-Kuang Shaw

  4. Department of Paediatrics, Tzu Chi General Hospital, Hualien, Taiwan

    Shu-Huey Chen

  5. Buddhist Tzu Chi Stem Cells Center, Hualien, Taiwan

    Shu-Huey Chen

Authors
  1. Ruey-Ho Kao
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  2. Chi-Cheng Li
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  3. Cheng-Kuang Shaw
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  4. Tso-Fu Wang
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  5. Sung-Chao Chu
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  7. Chao-Yuan Yao
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  8. Kuan-Po Huang
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  9. Yi-Feng Wu
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Correspondence to Ruey-Ho Kao.

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Kao, RH., Li, CC., Shaw, CK. et al. Correlation between characteristics of unrelated bone marrow donor and cell density of total nucleated cell in bone marrow harvest. Int J Hematol 89, 227–230 (2009). https://doi.org/10.1007/s12185-008-0235-8

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  • DOI: https://doi.org/10.1007/s12185-008-0235-8

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