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Veno-occlusive disease of the liver during induction therapy for acute lymphoblastic leukemia

International Journal of Hematology volume 88, pages 441–442 (2008)Cite this article

Abstract

Veno-occlusive disease (VOD) of the liver, also termed as sinusoidal obstruction syndrome, constitutes a well-known complication of high-dose cytoreductive chemotherapy prior to allogeneic or autologous bone marrow transplantation and is associated with the intensity of treatment [1]. On the contrary, there is only one report of VOD during induction therapy for acute lymphoblastic leukemia in a patient with Marfan syndrome, who was successfully treated with defibrotide [2]. In this article, we present the first fatal case of VOD during induction therapy for acute lymphoblastic leukemia.

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Affiliations

  1. First Propedeutic Department of Internal Medicine, AHEPA Hospital, Aristotle University, Thessaloníki, Greece

    Athanasios Papadopoulos, George Ntaios, Georgia Kaiafa, Fotios Girtovitis, Zoi Saouli, Zisis Kontoninas, Michael D. Diamantidis, Christos Savopoulos & Apostolos Hatzitolios

  2. S. Kiriakidi 1, AHEPA Hospital, 54636, Thessaloníki, Greece

    George Ntaios

Authors
  1. Athanasios Papadopoulos
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  2. George Ntaios
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  3. Georgia Kaiafa
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  4. Fotios Girtovitis
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  5. Zoi Saouli
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  6. Zisis Kontoninas
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  7. Michael D. Diamantidis
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  8. Christos Savopoulos
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  9. Apostolos Hatzitolios
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Corresponding author

Correspondence to George Ntaios.

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Papadopoulos, A., Ntaios, G., Kaiafa, G. et al. Veno-occlusive disease of the liver during induction therapy for acute lymphoblastic leukemia. Int J Hematol 88, 441–442 (2008). https://doi.org/10.1007/s12185-008-0172-6

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  • DOI: https://doi.org/10.1007/s12185-008-0172-6

Keywords

  • Veno-occlusive disease of the liver
  • Acute lymphoblastic leukemia
  • Induction therapy
  • Vincristine
  • Asparaginase