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Identification of a new HLA-Cw*07 allele, HLA-Cw*0743, from a Chinese hematopoietic stem cell donor

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Abstract

A new allele of the human leukocyte antigen C (HLA-C) locus was identified during routine HLA typing of a Chinese hematopoietic stem cell donor in Beijing, China. Sequence analysis of exons 2 and 3 of the HLA-C gene revealed the novel polymorphism. The closest matched allele was HLA-Cw*0710. A comparison of the two alleles showed that HLA-Cw*0743 carried a nucleotide substitution of C to A at codon 99 in exon 3, resulting in an amino acid substitution of serine to tyrosine with no obvious change in protein structure.

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Acknowledgments

We sincerely thank Dr. Z. X. Zhang (Beijing Red Cross Blood Center) for his technical assistance, Dr. H. X. Han (General hospital of Air-force) for his technical assistance in protein structure analysis. We are also grateful to Dr. J. F. Tisdale (National Institutes of Health) for a careful review of the manuscript. This work was supported, in part, by a grant from the National Natural Science Foundation of China (No. 30570776).

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Authors and Affiliations

  1. BMT Department, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China

    Haiyan Zhu, Dandan Zhao, Xiaoping Han, Jingfen Sun, Wanming Da, Li Yu & Chunji Gao

Authors
  1. Haiyan Zhu
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  2. Dandan Zhao
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  3. Xiaoping Han
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  4. Jingfen Sun
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  5. Wanming Da
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  6. Li Yu
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  7. Chunji Gao
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Corresponding author

Correspondence to Chunji Gao.

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Both Haiyan Zhu and Dandan Zhao are co-first authors.

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Zhu, H., Zhao, D., Han, X. et al. Identification of a new HLA-Cw*07 allele, HLA-Cw*0743, from a Chinese hematopoietic stem cell donor. Int J Hematol 88, 321–323 (2008). https://doi.org/10.1007/s12185-008-0145-9

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  • DOI: https://doi.org/10.1007/s12185-008-0145-9

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