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Long term platelet responses to Helicobacter pylori eradication in Canadian patients with immune thrombocytopenic purpura

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Abstract

This prospective Canadian pilot study assesses the platelet response rate in H. pylori positive and negative patients and evaluates potential mechanisms to explain response. Patients with ITP received H. pylori eradication therapy and platelet counts at day 56 were used to assess response. Gastric permeability, stool H. pylori antigen and serum CagA anti-body were done at baseline and at day 60. Twenty-two patients were enrolled with an overall response rate of 27% (6/22). The prevalence of H. pylori was 18% (4/22). Seventy-five percent of the H. pylori positive patients (3/4) achieved a response compared to 17% (3/18) of the H. pylori negative patients (P < 0.05). Seventy-five percent of complete responders have demonstrated long-term ongoing responses at 48 months of follow-up. A trend towards lower post-eradication gastric permeability in responders was seen. Although the prevalence of H. pylori is low, H. pylori positive Canadian patients with ITP may benefit from a trial of H. pylori eradication therapy as a safe and effective means to achieve long term platelet response.

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Acknowledgments

This project was supported by a research grant from Calgary Laboratory Services and Drs. Buret and O’Connor’s work on this project was supported by the Canadian Institutes for Health Research.

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Authors and Affiliations

  1. Division of Hematology, Department of Medicine, Foothills Medical Centre, 1403-29th Street N·W., Calgary, AB, T2N 2T9, Canada

    Shannon C. Jackson, Graham Pineo & Man-Chiu Poon

  2. Division of Gastroenterology, University of Calgary, Calgary, AB, Canada

    Paul Beck

  3. Department of Medicine and Department of Biological Sciences, University of Calgary, Calgary, AB, Canada

    Andre G. Buret & Pamela M. O’Connor

  4. Department of Medicine, University of Alberta, Edmonton, AB, Canada

    Jonathan Meddings

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  1. Shannon C. Jackson
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  2. Paul Beck
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  4. Pamela M. O’Connor
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  5. Jonathan Meddings
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  6. Graham Pineo
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Correspondence to Shannon C. Jackson.

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Jackson, S.C., Beck, P., Buret, A.G. et al. Long term platelet responses to Helicobacter pylori eradication in Canadian patients with immune thrombocytopenic purpura. Int J Hematol 88, 212–218 (2008). https://doi.org/10.1007/s12185-008-0138-8

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  • DOI: https://doi.org/10.1007/s12185-008-0138-8

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