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Clinical features of adult acute leukemia with 11q23 abnormalities in Japan: a co-operative multicenter study

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Abstract

To clarify the clinical features of adult patients with acute leukemia (AL) with 11q23 abnormalities, we performed a retrospective analysis of data from 58 adult Japanese patients: 51 with acute myeloid leukemia (AML), and 7 with acute lymphoblastic leukemia (ALL). The incidences according to fusion partners in AML were: t(9;11), 31.3%; t(11;19), 27.4%; t(6;11), 21.5%. The incidence of patients with t(11;19) was higher than those in the US and Europe, and the incidence of t(4;11) was lower than that in childhood. The results indicated the poor prognosis of AML with 11q23 abnormalities regardless of the fusion partners. AML patients with 11q23 aged <60 years in the first CR who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) showed a more favorable outcome than those treated without allo-HSCT, although the differences were not statistically significant (P = 0.322 for DFS, P = 0.138 for OS). This result suggests that treatment strategies including allo-HSCT may be considered in the first CR in cases of AML with 11q23 abnormalities. However, further studies involving a large number of cases are required to assess the effect of allo-HSCT on adult AL with 11q23 abnormalities.

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Acknowledgments

The authors thank the following institutions for providing patient data: Nippon Medical School, Tokyo, Japan; Musashino Red Cross Hospital, Tokyo, Japan; Saitama Medical University, Saitama, Japan; Tokyo Metropolitan Komagome Hospital, Tokyo, Japan; The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Jichi Medical School, Tochigi, Japan; Kanazawa University, Ishikawa, Japan; Tokyo Medical and Dental University, Tokyo, Japan; Yokosuka Kyosai Hospital, Kanagawa, Japan; Yokohama Minami Kyosai Hospital, Kanagawa, Japan; Tama Hokubu Medical Center, Tokyo, Japan; The Jikei University, Tokyo, Japan; Tokyo Medical University, Tokyo, Japan; Akita University, Akita, Japan; Juntendo University, Tokyo, Japan.

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Authors and Affiliations

  1. Department of Hematology, Nippon Medical School, Sendagi 1-1-5, Bunkyo-Ku, Tokyo, 113-8603, Japan

    Hayato Tamai, Hiroki Yamaguchi, Koiti Inokuchi & Kazuo Dan

  2. Department of Hematology, Musashino Red Cross Hospital, Tokyo, Japan

    Hiroyuki Hamaguchi

  3. Department of Hematology, Saitama Medical University, Saitama, Japan

    Fumiharu Yagasaki & Masami Bessho

  4. Department of Hematology, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan

    Takeshi Kobayashi, Hideki Akiyama & Hisashi Sakamaki

  5. Department of Hematology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

    Satoshi Takahashi & Arinobu Tojo

  6. Department of Hematology, Jichi Medical School, Tochigi, Japan

    Ken Ohmine & Keiya Ozawa

  7. Department of Hematology, Kanazawa University, Ishikawa, Japan

    Hirokazu Okumura & Shinji Nakao

  8. Department of Hematology, Tokyo Medical and Dental University, Tokyo, Japan

    Ayako Arai & Osamu Miura

  9. Department of Hematology, Yokosuka Kyosai Hospital, Kanagawa, Japan

    Shigeo Toyota

  10. Department of Hematology, Yokohama Minami Kyosai Hospital, Kanagawa, Japan

    Seiji Gomi

  11. Department of Hematology, Tama Hokubu Medical Center, Tokyo, Japan

    Yoshiro Murai

  12. Department of Hematology, The Jikei University, Tokyo, Japan

    Noriko Usui

  13. Department of Hematology, Tokyo Medical University, Tokyo, Japan

    Keisuke Miyazawa & Kazuma Ohyashiki

  14. Department of Internal Medicine, Akita University, Akita, Japan

    Naoto Takahashi & Kenichi Sawada

  15. Department of Hematology, Juntendo University, Tokyo, Japan

    Atsushi Kato & Kazuo Oshimi

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  1. Hayato Tamai
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  2. Hiroki Yamaguchi
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Correspondence to Hayato Tamai.

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Tamai, H., Yamaguchi, H., Hamaguchi, H. et al. Clinical features of adult acute leukemia with 11q23 abnormalities in Japan: a co-operative multicenter study. Int J Hematol 87, 195–202 (2008). https://doi.org/10.1007/s12185-008-0034-2

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  • DOI: https://doi.org/10.1007/s12185-008-0034-2

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