Skip to main content

Advertisement

SpringerLink
Log in

Innovation in Orthopaedics: Part 2—How to Translate Ideas and Research into Clinical Practice

  • Emerging Trends in Design for Musculoskeletal Medicine (S Goldchmit and M Queiroz, Section Editors)
  • Published:
Current Reviews in Musculoskeletal Medicine Aims and scope Submit manuscript

Abstract

Purpose of Review

This paper presents some approaches and techniques for translating an idea or research into clinical practice, considering the innovation development process.

Recent Findings

Innovative tools have been a key solution for healthcare problems, such as musculoskeletal disorders, which represent a great economic burden and are among the leading causes of disability. There has been an increase in publications on this topic, but there has been no analysis of the process of innovation development. This review describes the innovation phases for translating an idea or research into clinical practice, considering the stages of discovering the opportunity, innovation creation, project specification, technology development, and innovation launch.

Summary

An analysis of the innovation development process to translate an idea or research into clinical practice, including concepts, approaches, and techniques that shows the “why”, “how”, and “what” of innovation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Maher SA, Kyle R, Morrey BF, Yaszemski MJ. Translating orthopaedic technologies into clinical practice. J Am Acad Orthop Surg. 2018;1:e9–e16. https://doi.org/10.5435/jaaos-d-17-00851.

    Article  Google Scholar 

  2. Garas G, Cingolani I, Panzarasa P, Darzi A, Athanasiou T. Network analysis of surgical innovation: measuring value and the virality of diffusion in robotic surgery. PLoS One. 2017;12(8):e0183332. https://doi.org/10.1371/journal.pone.0183332.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Snow F. Creativity and innovation: an essential competency for the nurse leader. Nurs Adm Q. 2019;43(4):306–12. https://doi.org/10.1097/NAQ.0000000000000367.

    Article  PubMed  Google Scholar 

  4. Sternberg RJ. Whence creativity? J Creat Behav. 2017;51(4):289–92. https://doi.org/10.1002/jocb.199.

    Article  Google Scholar 

  5. Lubart TI. Models of the creative process: past, present and future. Creat Res J. 2001;13(3-4):295–308. https://doi.org/10.1207/s15326934crj1334_07.

    Article  Google Scholar 

  6. Wallas G. The art of thought. New York: Harcourt Brace; 1926.

    Google Scholar 

  7. Sternberg RJ. Creativity from start to finish: a “straight-a” model of creative process and its relation to intelligence. J Creat Behav. 2017;54:229–41. https://doi.org/10.1002/jocb.223.

    Article  Google Scholar 

  8. Patterson F, Zibarras LD. Selecting for creativity and innovation potential: implications for practice in healthcare education. Adv Health Sci Educ. 2017;22(2):417–28. https://doi.org/10.1007/s10459-016-9731-4Highlights the importance of creativity and innovation for healthcare education, demonstrating how motivation plays an important role.

    Article  Google Scholar 

  9. Maher, S. A., Kyle, R., Morrey, B. F., & Yaszemski, M. J. (2018). Translating orthopaedic technologies into clinical practice. J Am Acad Orthop Surg, 1. https://doi.org/10.5435/jaaos-d-17-00851. Identifies challenges and solutions on translating a technology to clinical use for musculoskeletal entrepreneurs who want to transform patient care.

  10. Poduval M, Ghose A, Manchanda S, Bagaria V, Sinha A. Artificial intelligence and machine learning: a new disruptive force in orthopaedics. Indian J Orthop. 2020;54(2):109–22. https://doi.org/10.1007/s43465-019-00023-3 PMID: 32257027; PMCID: PMC7096590.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Campbell KJ, Louie PK, Khorsand DA, Frisch NB, Gerlinger TL, Levine BR. Innovation and entrepreneurship: perspectives from orthopedic surgery. Orthopedics. 2018;41(3):135–40. https://doi.org/10.3928/01477447-20180409-08 Epub 2018 Apr 16.

    Article  PubMed  Google Scholar 

  12. Sinek S. Start with why: how great leaders inspire everyone to take action. London: Penguin Group; 2009.

    Google Scholar 

  13. Zhang Y-Z. Brave to advance the theoretical and technological innovation on the basis of orthopedic practice. Chin Med J. 2018;131(21):2521–3. https://doi.org/10.4103/0366-6999.244123.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Jupiter JB, Gruber JS. Innovation and innovators: does it take 10,000 hours? J Hand Surg. 2012;37(7):1447–52. https://doi.org/10.1016/j.jhsa.2012.03.041.

    Article  Google Scholar 

  15. Miaskiewicz T, Kozar KA. Personas and user-centered design: how can personas benefit product design processes? Des Stud. 2011;32(5):417–30. https://doi.org/10.1016/j.destud.2011.03.003.

    Article  Google Scholar 

  16. McLaughlin JE, Wolcott MD, Hubbard D, Umstead K, Rider TR. A qualitative review of the design thinking framework in health professions education. BMC Med Educ. 2019;19(1). https://doi.org/10.1186/s12909-019-1528-8This study reviews the use of the design thinking in health professionals’ education to assess how this framework has been applied.

  17. Roberts JP, Fisher TR, Trowbridge MJ, Bent C. A design thinking framework for healthcare management and innovation. Healthcare. 2016;4(1):11–4. https://doi.org/10.1016/j.hjdsi.2015.12.002.

    Article  PubMed  Google Scholar 

  18. Design Council. What is the framework for innovation? Design council’s evolved double diamond. 2019; online, available: https://www.designcouncil.org.uk/news-opinion/what-framework-innovation-design-councils-evolved-double-diamond. [Accessed: 08-Jun-2021].

  19. Mariana de Mendonça Molles Mazzini Perpétuo. Um estudo da aplicação de design sprint para redesenho de processos. Projeto de Graduação ao Curso de Engenharia de Produção da Escola Politécnica, Universidade Federal do Rio de Janeiro

  20. Jake-Schoffman DE, McVay MA. Using the design sprint process to enhance and accelerate behavioral medicine progress: a case study and guidance. Transl Behav Med. 2020 Oct 15:ibaa100. https://doi.org/10.1093/tbm/ibaa100.

  21. Zheng MH, Sun J, Jiang TY, Ma JJ. Scientific and technological innovation and achievement transformation promote the medical development. Zhonghua Wei Chang Wai Ke Za Zhi. 2020;23(6):541–4. Chinese. https://doi.org/10.3760/cma.j.cn.441530-20200331-00175.

    Article  CAS  PubMed  Google Scholar 

  22. Wall J, Wynne E, Krummel T. Biodesign process and culture to enable pediatric medical technology innovation. Semin Pediatr Surg. 2015;24(3):102–6. https://doi.org/10.1053/j.sempedsurg.2015.02.005 Epub 2015 Mar 2.

    Article  PubMed  Google Scholar 

  23. Kirtley J, O’Mahony S. What is a pivot? Explaining when and how entrepreneurial firms decide to make strategic change and pivot. Strateg Manag J. 2020. https://doi.org/10.1002/smj.3131Describes what a pivot means and how and when entrepreneurial firms choose to change their strategies.

  24. Kendig CE. What is proof of concept research and how does it generate epistemic and ethical categories for future scientific practice? Sci Eng Ethics. 2015;22(3):735–53. https://doi.org/10.1007/s11948-015-9654-0.

    Article  PubMed  Google Scholar 

  25. Park Y-B, Ha C-W, Lee C-H, Yoon YC, Park Y-G. Cartilage regeneration in osteoarthritic patients by a composite of allogeneic umbilical cord blood-derived mesenchymal stem cells and hyaluronate hydrogel: results from a clinical trial for safety and proof-of-concept with 7 years of extended follow-Up. Stem Cells Transl Med. 2016;6(2):613–21. https://doi.org/10.5966/sctm.2016-0157.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Fernandes TL, Shimomura K, Asperti A, Pinheiro CCG, Caetano HVA, Oliveira CRGCM, Nakamura N, Hernandez AJ, Bueno DF. Development of a novel large animal model to evaluate human dental pulp stem cells for articular cartilage treatment. Stem Cell Rev Rep. 2018;14(5):734–43. https://doi.org/10.1007/s12015-018-9820-2 PMID: 29728886; PMCID: PMC6132738.

    Article  CAS  PubMed  Google Scholar 

  27. Umscheid CA, Margolis DJ, Grossman CE. Key concepts of clinical trials: a narrative review. Postgrad Med. 2011;123(5):194–204. https://doi.org/10.3810/pgm.2011.09.2475.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Tanikawa D, Pinheiro C, Almeida M, Oliveira C, Coudry RA, Rocha DL, Bueno DF. Deciduous dental pulp stem cells for maxillary alveolar reconstruction in cleft lip and palate patients. Stem Cells Int. 2020;2020:6234167. https://doi.org/10.1155/2020/6234167.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Dharmawan R, Ho H, Ng HHM, Iyer NG, Tan HK, Tan NC. Implementing the biodesign process for medical device innovation in head and neck surgery. Surg Innov. 2020 Dec;27(6):653–8. https://doi.org/10.1177/1553350620943796 Epub 2020 Jul 30.

  30. Kelly CJ, Young AJ. Promoting innovation in healthcare. Future Healthcare J. 2017;4(2):121–5. https://doi.org/10.7861/futurehosp.4-2-121Explores the aspects of innovating in healthcare, including definition, key points on creating a culture for innovation and possible issues.

    Article  Google Scholar 

  31. Judd DB. Open innovation and intellectual property: time for a reboot? Drug Discov Today. 2013;18(19-20):907-909. https://doi.org/10.1016/j.drudis.2013.08.008. Epub 2013 Aug 16. Introduces the main forms of intellectual property and its legal aspects.

  32. Voss T, Paranjpe AS, Cook TG, Garrison NDW. A Short introduction to intellectual property rights. Tech Vasc Interv Radiol. 2017;20(2):116–20. https://doi.org/10.1053/j.tvir.2017.04.007 Epub 2017 Apr 18.

    Article  PubMed  Google Scholar 

  33. Zheng MH, Willers C, Kirilak I, Yates P, Xu J, Wood D, Shimmin A. Matrix-induced autologous chondrocyte implantation (MACI) biological and histological assessment. Tissue Eng. 2007;13:737–46.

    Article  CAS  Google Scholar 

  34. Matrix-Induced autologous chondrocyte implantation (MACI) using a cell-seeded collagen membrane improves cartilage healing in the equine model. Alan J. Nixon, BVSc, MS, Holly D. Sparks, DVM, Laila Begum, PhD, Sean McDonough, DVM, PhD, Michael S. Scimeca, MS, Nance Moran, PhD, and Gloria L. Matthews, DVM, PhD. J Bone Joint Surg. 2017; 99(23):1987-1998

  35. Behrens P, Bitter T, Kurz B, Russlies M. Matrix-associated autologous chondrocyte transplantation/implantation (MACT/MACI)-5 year follow-up. Knee. 2006;13(3):194–202.

    Article  Google Scholar 

  36. Matrix-applied characterized autologous cultured chondrocytes versus microfracture: five-year follow-up of a prospective randomized trial.

Download references

Author information

Authors and Affiliations

  1. Sports Medicine Division, Institute of Orthopedics and Traumatology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, 333 Dr. Ovídio Pires de Campos, 05403-010, Sao Paulo, SP, Brazil

    Tiago Lazzaretti Fernandes & Rafaella Rogatto de Faria

  2. Design Department, School of Architecture and Urbanism, Universidade de Sao Paulo, Sao Paulo, SP, Brazil

    Maria Alice Gonzales & Sara Goldchmit

  3. Department of Orthopaedic Surgery, Stanford University, Stanford, CA, USA

    Seth L. Sherman

  4. Production Engineering Department, School of Engineering, Universidade de Sao Paulo, Sao Paulo, SP, Brazil

    Andre Fleury

Authors
  1. Tiago Lazzaretti Fernandes
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rafaella Rogatto de Faria
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Maria Alice Gonzales
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Seth L. Sherman
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Sara Goldchmit
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Andre Fleury
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Tiago Lazzaretti Fernandes.

Ethics declarations

Conflict of Interest

The authors declare no competing interests.

Human and Animal Rights and Informed Consent

This article does not contain any studies involving human or animal subjects performed by any of the authors.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This article is part of the Topical Collection on Emerging Trends in Design for Musculoskeletal Medicine

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Fernandes, T.L., de Faria, R.R., Gonzales, M.A. et al. Innovation in Orthopaedics: Part 2—How to Translate Ideas and Research into Clinical Practice. Curr Rev Musculoskelet Med 15, 150–155 (2022). https://doi.org/10.1007/s12178-022-09749-4

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12178-022-09749-4

Keywords

Search

Navigation