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The Clinical Use of Biologics in the Knee Lesions: Does the Patient Benefit?

  • Outcomes Research in Orthopedics (O Ayeni, Section Editor)
  • Published:
Current Reviews in Musculoskeletal Medicine Aims and scope Submit manuscript


Purpose of Review

Overview the outcomes of the latest use of platelet-rich plasma (PRP) for the treatment of knee lesions in the clinics and discuss the challenges and limitations.

Recent Findings

Recent clinical studies mainly indicate there may be benefit of PRP usage for the treatment of knee lesions. As an autologous source of bioactive components, PRP has been shown to be typically safe, free of major adverse outcomes. The use of PRP has been continuously increasing, and some well-designed, double-blinded, placebo-controlled clinical trials have been published.


Clinical outcomes relating to PRP usage are multifactorial and depend on the severity of the lesion and patient characteristics. Although PRP is safe to use and it can be easily applied in the clinics, case-specific considerations are needed to determine whether PRP could be beneficial or not. If the use of PRP is favored, then, the configuration/optimization of the preparation and administration/delivery strategy with or without a concomitant treatment may further enhance the clinical outcomes and patients’ experience.

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The authors would like to thank the Portuguese Foundation for Science and Technology (FCT) project M-ERA-NET/0001/2014 project. This work is also a result of the project FROnTHERA

(NORTE-01-0145-FEDER-000023), supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). IFC thanks the FCT for the grant SFRH/BD/99555/2014. JMO also thanks the FCT for the funds provided under the program Investigador FCT 2015 (IF/01285/2015).

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Correspondence to Ibrahim Fatih Cengiz.

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Cengiz, I.F., Pereira, H., Espregueira-Mendes, J. et al. The Clinical Use of Biologics in the Knee Lesions: Does the Patient Benefit?. Curr Rev Musculoskelet Med 12, 406–414 (2019).

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