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Clinical Update: Why PRP Should Be Your First Choice for Injection Therapy in Treating Osteoarthritis of the Knee


Purpose of Review

The purpose of this review is to update the reader on the current applications of platelet-rich plasma (PRP) in the treatment of knee osteoarthritis (KOA). This review will focus on PRP’s effect on the osteoarthritic joint, how PRP compares to traditional treatments of KOA, and provide clinical feedback on the use of PRP in an orthopedic and sports medicine practice.

Recent Findings

Recent research into the applications of PRP for KOA has further indicated both the efficacy and safety of PRP treatment. Although research has shown a tendency toward better efficacy at earlier stages of osteoarthritis (OA), evidence exists to indicate positive effects at all stages of OA.


In summary, since KOA is an extremely prevalent condition that can be a challenge to treat, it is imperative that safe and effective nonoperative treatment methods be available to individuals that are suffering from this condition.

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Papers of particular interest, published recently, have been highlighted as: • Of importance

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Correspondence to Patrick A. Smith.

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Dr. Smith is a consultant for Arthrex and receives research support from them.

Dr. Cook has no conflicts of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Protein-Rich Plasma: From Bench to Treatment of Arthritis

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Cook, C.S., Smith, P.A. Clinical Update: Why PRP Should Be Your First Choice for Injection Therapy in Treating Osteoarthritis of the Knee. Curr Rev Musculoskelet Med 11, 583–592 (2018). https://doi.org/10.1007/s12178-018-9524-x

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  • Knee
  • Osteoarthritis
  • PRP
  • Platelet-rich plasma
  • Intra-articular