Platelet-Rich Plasma: Review of Current Literature on its Use for Tendon and Ligament Pathology


Purpose of review

Platelet-rich plasma (PRP) contains numerous growth factors and cytokines that potentially offer an alternative treatment modality to assist in the healing of multiple musculoskeletal issues. The purpose of this review was to examine the latest literature on the use of PRP for various ligament and tendon pathologies.

Recent findings

Recent literature has shown moderate- to high-quality evidence that PRP can have positive clinical effects in certain conditions such as lateral epicondylitis and rotator cuff tendinopathy. Prospective studies have shown that it can also be useful in the treatment of patella tendinopathy.


In summary, we found PRP to have variable success in ligament and tendon pathology; however, it should be considered a viable option in chronic musculoskeletal disease that has failed other treatments. Patient selection, duration of symptoms, and combining with other modalities such as physical therapy should all be taken into consideration in treatment with PRP.

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Correspondence to Cameron Kia.

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Conflict of interest

Dr. Mazzocca is a consultant for Arthrex, Inc. and has received financial support from the biomechanics lab. All other authors declare no conflicts of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Protein-Rich Plasma: From Bench to Treatment of Arthritis

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Kia, C., Baldino, J., Bell, R. et al. Platelet-Rich Plasma: Review of Current Literature on its Use for Tendon and Ligament Pathology. Curr Rev Musculoskelet Med 11, 566–572 (2018).

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  • Platelet-rich plasma
  • PRP
  • Tendinopathy
  • Ligament
  • Biologics