Gene and cell therapy for muscle regeneration

  • Roberta Sessa Stilhano
  • Leonardo Martins
  • Sheila Jean McNeill Ingham
  • João Bosco Pesquero
  • Johnny Huard
Muscle Injuries (SJ McNeill Ingham, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Muscle Injuries


Skeletal muscle injury and healing are multifactorial processes, involving three steps of healing: (1) degeneration and inflammation, (2) regeneration, and (3) fibrosis. Fibrous tissue hinders the muscle’s complete recovery and current therapies fail in achieving total muscle recovery. Gene and cell therapy (or both) are potential future treatments for severe muscular injuries. Stem cells’ properties associated with growth factors or/and cytokines can improve muscle healing and permit long-term recovery.


Gene therapy Cell therapy Muscle injury Fibrosis Stem cell Growth factor 


Compliance with Ethics Guidelines

Conflict of Interest

Roberta Sessa Stilhano, Leonardo Martins, Sheila Jean McNeill Ingham, and João Bosco Pesquero declare that they have no conflict of interest.

Johnny Huard receives consulting fees and royalties from Cook MyoSite Inc.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Roberta Sessa Stilhano
    • 1
  • Leonardo Martins
    • 1
  • Sheila Jean McNeill Ingham
    • 2
  • João Bosco Pesquero
    • 1
  • Johnny Huard
    • 3
  1. 1.Biophysics DepartmentFederal University of São Paulo - UNIFESPSão PauloBrazil
  2. 2.Department of Orthopaedic SurgeryFederal University of São PauloSão PauloBrazil
  3. 3.Stem Cell Research Center, Department of Orthopaedic Surgery, and Department of BioengineeringUniversity of PittsburghPittsburghUSA

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