Saturated Fat and Cardiovascular Disease: A Review of Current Evidence
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Cardiovascular disease (CVD) is one of the leading causes of death throughout the world. Saturated fatty acids (SFA) have long been implicated in the development of CVD. The evidence to support this hypothesis came from studies which examined the effects of SFA intake on total cholesterol (TC). However, relying on TC as the sole primary outcome may not be sufficient and understanding the effect of SFA on the concentrations of other lipid fractions is necessary. SFA are known to increase low-density lipoprotein cholesterol (LDL-C) and consequently dietary guidelines recommend reducing SFA intakes in order to decrease LDL-C and CVD risk. However, recent evidence suggests that not all SFAs possess the same atherogenic properties but this development has not yet been reflected in dietary recommendations. This review summarizes recent evidence on the relationship between SFA intake and CVD risk. It also explores current dietary guidelines specific to SFA intake and outlines why future guidelines may need to be food- rather than nutrient-specific. Overall, the evidence presented in this review suggests that not all SFA are created equal and the food sources of SFA, as well as individual characteristics of the SFA, such as chain length, should be considered in dietary recommendations.
KeywordsCardiovascular disease Saturated fat Dairy Meat Dietary guidelines
American Heart Association
Beef Optimal in Lean Diet
Coronary heart disease
Dietary Approaches to Stop Hypertension
European Food Safety Authority
Food frequency questionnaire
Healthy American Diet
High-density lipoprotein cholesterol
Institute of Medicine
Low-density lipoprotein cholesterol
Mono-unsaturated fatty acid
Saturated fatty acids
Tumor necrosis factor-alpha
United States Department of Agriculture
United States Department of Health and Human Services
No potential conflicts of interest relevant to this article were reported.
- 5.Xu J., et al. Deaths: final data for 2007, 2010, National Center for Health Statistics: Hyattsville, MD. p. 1-135.Google Scholar
- 8.CDC, Racial/ethnic and socioeconomic disparities in multiple risk factors for heart disease and stroke–United States, 2003. in Morbidity and Mortality Weekly Report 2003.113-7.Google Scholar
- 9.Long Y et al. Analysis of the prevalence of cardiovascular disease and associated risk factors for European-American and African-American Populations in the State of Pennsylvania 2005-2009. Am J Cardiol. 2012. doi: 10.1016/j.amjcard.2012.08.045.
- 13.Keys A. Coronary heart disease in seven countries. Circulation. 1970;41(S1):1–211.Google Scholar
- 16.Multiple risk factor intervention trial. Risk factor changes and mortality results. Multiple Risk Factor Intervention Trial Research Group. JAMA 1982;248(12):1465-77.Google Scholar
- 22.USDA/UDHHS, Report of the Dietary Guidelines Advisory Committee on the dietary guidelines for Americans, 2010, U.S.D.o. Agriculture and U.S.D.o.H.a.H. Services, Editors. 2010.Google Scholar
- 23.American Heart Association Nutrition Committee, Lichtenstein AH, Appel LJ, Brands M, Carnethon M, Daniels S, Franch HA, Franklin B, Kris-Etherton P, Harris WS, Howard B, Karanja N, Lefevre M, Rudel L, Sacks F, Van Horn L, Winston M, Wylie-Rosett J. Diet and lifestyle recommendations revision 2006: a scientific statement from the American Heart Association Nutrition Committee. Circulation 2006;114(1):82-96.Google Scholar
- 24.Medicine, I.O., Dietary fats: total fat and fatty acids. In: Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein and amino acids (macronutrients), 2005.Google Scholar
- 25.EFSA, Scientific Opinion on Dietary Reference Values for fats, including saturated fatty acids, polyunsaturated fatty acids, monounsaturated fatty acids, trans fatty acids, and cholesterol. ESFA J. 2010;8(3):1461.Google Scholar
- 33.van Aerde, M.A., et al., Dairy intake in relation to cardiovascular disease mortality and all-cause mortality: the Hoorn Study. Eur J Nutr. 2012;Google Scholar
- 46.http://riskfactor.cancer.gov/diet/foodsources/sat_fat/. Sources of Saturated Fat, Stearic Acid, & Cholesterol Raising Fat among the US Population, 2005–06. 2010 [cited 2012 November 28].
- 48.http://www.hsph.harvard.edu/nutritionsource/what-should-you-eat/dietary-guidelines-2010/index.html. 2012 [cited 2012 October 21].
- 68.Mateo-Gallego, R., et al., Effect of lean red meat from lamb v. lean white meat from chicken on the serum lipid profile: a randomised, cross-over study in women. Br J Nutr. 2012;107(10):1403-7.Google Scholar
- 79.Chiu MC, De C, Coutinho M, Aparecida L, Goncalves G. Carotenoid concentration of red palm oil using membrane technology. Desalination. 2009;246:410–3.Google Scholar
- 85.DebMandal M, Mandal S. Coconut (Cocos nucifera L.: Arecaceae): in health promotion and disease prevention. Asian Pac. J Trop Med. 2011;4(3):241–7.Google Scholar
- 88.USDA. http://ndb.nal.usda.gov. 2011 [cited 2012 December 1].