Food Analytical Methods

, Volume 11, Issue 9, pp 2447–2454 | Cite as

Rapid Food Product Analysis by Surface Acoustic Wave Nebulization Coupled Mass Spectrometry

  • Thomas Schneider
  • Benjamin L. Oyler
  • Sung Hwan Yoon
  • Tao Liang
  • Gloria S. Yen
  • David P. A. Kilgour
  • Erik Nilsson
  • David R. Goodlett


Rapid food product analysis is of great interest for quality control and assurance during the production process. Conventional quality control protocols require time and labor-intensive sample preparation for analysis by state-of-the-art analytical methods. To reduce overall cost and facilitate rapid qualitative assessments, food products need to be tested with minimal sample preparation. We present a novel and simple method for assessing food product compositions by mass spectrometry using a novel surface acoustic wave nebulization method. This method provides significant advantages over conventional methods requiring no pumps, capillaries, or additional chemicals to enhance ionization for mass spectrometric analysis. In addition, the surface acoustic wave nebulization–mass spectrometry method is ideal for rapid analysis and to investigate certain compounds by using the mass spectra as a type of species-specific fingerprint analysis. We present for the first time surface acoustic wave nebulization-generated mass spectra of a variety of fermented food products from a small selection of vinegars, wines, and beers.


Mass spectrometry Surface acoustic wave nebulization Vinegar, wine, and beer analysis 



This study was funded by the National Institute of Health (Grant 1R01 GM111066-01, D.R.G) and National Science Foundation (Grant 1330459; Deurion LLC). Parts of the study are based upon work supported by the National Science Foundation (Grant no. IIP-1059286 to the American Society for Engineering Education). Additional thanks are due to the University of Maryland School of Pharmacy Mass Spectrometry Center (SOP1841-IQB2014).

Compliance with Ethical Standards

Conflict of Interest

Thomas Schneider declares that he has no conflict of interest. David P. A. Kilgour declares that he has no conflict of interest. Erik Nilsson declares that he has no conflict of interest. David R. Goodlett has financial interests in Deurion LLC.

Ethical Approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed Consent

Not applicable.

Supplementary material

12161_2018_1232_MOESM1_ESM.docx (10 mb)
ESM 1 (DOCX 10191 kb)


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Thomas Schneider
    • 1
  • Benjamin L. Oyler
    • 2
  • Sung Hwan Yoon
    • 3
  • Tao Liang
    • 1
  • Gloria S. Yen
    • 4
  • David P. A. Kilgour
    • 5
  • Erik Nilsson
    • 4
  • David R. Goodlett
    • 1
    • 4
  1. 1.Department of Pharmaceutical Sciences, School of PharmacyUniversity of MarylandBaltimoreUSA
  2. 2.Department of Toxicology, School of MedicineUniversity of MarylandBaltimoreUSA
  3. 3.Department of Microbial Pathogenesis, School of DentistryUniversity of MarylandBaltimoreUSA
  4. 4.Deurion LLCSeattleUSA
  5. 5.Chemistry and Forensics, School of Science & TechnologyNottingham Trent UniversityNottinghamUK

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