Skip to main content

Advertisement

SpringerLink
Log in

Nanostructured Sensor for Simultaneous Determination of Trace Amounts of Bisphenol A and Vitamin B6 in Food Samples

  • Published:
Food Analytical Methods Aims and scope Submit manuscript

Abstract

Rapid analysis of health hazardous materials is necessary to prevent foodborne illness in food control science. Bisphenol A (BPA) is one of the potentially hazardous materials that may potentially create adverse health effects, if its concentration level in food is not controlled. In this work, carbon paste electrode has been modified with CdO nanoparticles and ionic liquid (IL/CdO/CPE) for determination of BPA in food samples. In addition, vitamin B6 (B6) has separated oxidation peak at modified electrode and simultaneous determination of BPA and B6 is possible. The square wave voltammetric peak currents of BPA and B6 at IL/CdO/CPE have linear relation to their concentrations in the range of 0.01 to 800 μmol L−1 BPA and 0.4 to 500 μmol L−1 B6. Selectivity of the modified electrode was studied, and it was successfully applied for analysis of food samples.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  • Acevedo N, Davis B, Schaeberle CM, Sonnenschein C, Soto AM (2009) Perinatally administered bisphenol a as a potential mammary gland carcinogen in rats. Environ Health Persp 121:1040–1046

    Google Scholar 

  • Afsharmanesh E, Karimi-Maleh H, Pahlavan A, Vahedi J (2013) Electrochemical behavior of morphine at ZnO/CNT nanocomposite room temperature ionic liquid modified carbon paste electrode and its determination in real samples. J Mol Liq 181:8–13

    Article  CAS  Google Scholar 

  • ASTM (2011) American Society of the International Association for Testing and Materials: standard test method for determination of nonylphenol, bisphenol A, p-tert-octylphenol, nonylphenol monoethoxylate and nonylphenol diethoxylate in environmental waters by gas chromatography mass spectrometry ASTM D7065, http://www.astm.org/Standards/D7065.htm. Accessed 28 June 2016

  • ASTM (2016) American Society of the International Association for Testing and Materials: standard test method for determination of bisphenol A in environmental waters by liquid chromatography/tandem mass spectrometry ASTM D7574, http://www.astm.org/Standards/D7574.htm. Accessed 28 June 2016

  • Bader M (1980) A systematic approach to standard addition methods in instrumental analysis. J Chem Edu 57:703–706

    Article  CAS  Google Scholar 

  • Baghizadeh A, Karimi-Maleh H, Khoshnama Z, Hassankhani A, Abbasghorbani M (2015) A voltammetric sensor for simultaneous determination of vitamin C and vitamin B6 in food samples using ZrO2 nanoparticle/ionic liquids carbon paste electrode. Food Anal Method 8:549–557

    Article  Google Scholar 

  • Beitollah H, Goodarzian M, Khalilzadeh MA, Karimi-Maleh H (2012) Electrochemical behaviors and determination of carbidopa on carbon nanotubes ionic liquid paste electrode. J Mol Liq 173:137–143

    Article  CAS  Google Scholar 

  • Bijad M, Karimi-Maleh H, Khalilzadeh MA (2013) Application of ZnO/CNTs nanocomposite ionic liquid paste electrode as a sensitive voltammetric sensor for determination of ascorbic acid in food samples. Food Anal Method 6:1639–1647

    Article  Google Scholar 

  • Brunetti B, Desimoni E (2014) Voltammetric determination of vitamin B6 in food samples and dietary supplements. J Food Comp Anal 33:155–160

    Article  CAS  Google Scholar 

  • Dianin AP (1891) On condensation products of ketones with phenols. J Russ Phys Chem Soc 23:491–493

    Google Scholar 

  • Elyasi M, Khalilzadeh MA, Karimi-Maleh H (2013) High sensitive voltammetric sensor based on Pt/CNTs nanocompositemodified ionic liquid carbon paste electrode for determination of Sudan I in food samples. Food Chem 141:4311–4317

    Article  CAS  Google Scholar 

  • Ensafi AA, Karimi-Maleh H (2010) Modified multiwall carbon nanotubes paste electrode as a sensor for simultaneous determination of 6-thioguanine and folic acid using ferrocenedicarboxylic acid as a mediator. J Electroanal Chem 640:75–83

    Article  CAS  Google Scholar 

  • Ensafi AA, Karimi-Maleh H, Mallakpour S, Hatami M (2011) Simultaneous determination of N-acetylcysteine and acetaminophen by voltammetric method using N-(3, 4-dihydroxyphenethyl)-3, 5-dinitrobenzamide modified multiwall carbon nanotubes paste electrode. Sensors Actuators B Chem 155:464–472

    Article  CAS  Google Scholar 

  • Eren T, Atar N, Yola L, Karimi-Maleh H (2015) A sensitive molecularly imprinted polymer based quartz crystal microbalance nanosensor for selective determination of lovastatin in red yeast rice. Food Chem 185:430–436

    Article  CAS  Google Scholar 

  • Erler C, Novak J (2010) Bisphenol A exposure: human risk and health policy. J Pediatr Nur 25:400–407

    Article  Google Scholar 

  • FDA (2014) U.S. Food and Drug Administration: final report for the review of literature and data on BPA, http://www.fda.gov/downloads/Food/IngredientsPackagingLabeling/FoodAdditivesIngredients/UCM424011.Pdf. Accessed 28 June 2016

  • Feng J, Xu L, Cui G, Wu X, Ma W, Kuang H, Xu C (2016) Building SERS-active heteroassemblies for ultrasensitive bisphenol A detection. Biosens Bioelectron 81:138–142

    Article  CAS  Google Scholar 

  • Fouladgar M (2015) Direct voltammetric determination of dobutamine in pharmaceutical samples using multiwall carbon nanotubes paste electrode. ECS Solid State Lett 4:M15–M18

    Article  CAS  Google Scholar 

  • Fouladgar M (2016a) Application of ZnO nanoparticle/ion liquid modified carbon paste electrode for determination of isoproterenol in pharmaceutical and biological samples. J Electrochem Soc 163:B38–B42

    Article  CAS  Google Scholar 

  • Fouladgar M (2016b) A new sensor for determination of nalbuphine using NiO/functionalsingle walled carbon nanotubes nanocomposite and ionic liquid. Sensors Actuators B Chem 230:456–462

    Article  CAS  Google Scholar 

  • Fouladgar M, Karimi-Maleh H (2013) Ionic liquid/multiwall carbon nanotubes paste electrode for square wave voltammetric determination of methyldopa. Ionics 19:1163–1170

    Article  CAS  Google Scholar 

  • Fouladgar M, Mohammadzadeh S (2014) Determination of methimazole on a multiwall carbon nanotube titanium dioxide nanoparticle paste electrode. Anal Lett 47:763–777

    Article  CAS  Google Scholar 

  • García-Prieto A, Lunar ML, Rubio S, Pérez-Bendito D (2008) Determination of urinary bisphenol A by coacervative microextraction and liquid chromatography–fluorescence detection. Anal Chim Acta 630:19–27

    Article  Google Scholar 

  • Haighton LA, Hlywka JJ, Doull J, Kroes R, Lynch BS, Munro IC (2002) An evaluation of the possible carcinogenicity of bisphenol A to humans. Regul Toxicol Pharmacol 35:238–254

    Article  CAS  Google Scholar 

  • ISO (2009) The International Organization for Standardization: determination of selected alkylphenols—part 2: gas chromatographic-mass spectrometric determination of alkylphenols, their ethoxylates and bisphenol A in non-filtered samples following solid-phase extraction and derivatisation ISO 18857-2, http://www.iso.org/iso/home/store/catalogue_tc/catalogue_detail.htm?csnumber=34673. Accessed 28 June 2016

  • Kang M, Lee B (2016) Sensing of bisphenol A and mercury ions in aqueous solutions using a functionalized porous gold electrode. Curr Appl Phys 16:446–452

    Article  Google Scholar 

  • Karimi-Maleh H, Biparva P, Hatami M (2013) A novel modified carbon paste electrode based on NiO/CNTs nanocomposite and (9, 10-dihydro-9, 10-ethanoanthracene-11, 12-dicarboximido)-4-ethylbenzene-1, 2-diol as a mediator for simultaneous determination of cysteamine, nicotinamide adenine dinucleotide and folic acid. Biosens Bioelectron 48:270–275

    Article  CAS  Google Scholar 

  • Karimi-Maleh H, Tahernejad-Javazmi F, Ensafi AA, Moradi R, Mallakpour S, Beitollahi H (2014) A high sensitive biosensor based on FePt/CNTs nanocomposite /N-(4-hydroxyphenyl)-3,5-dinitrobenzamide modified carbon paste electrode for simultaneous determinationof glutathione and piroxicam. Biosens Bioelectron 60:1–7

    Article  CAS  Google Scholar 

  • Kashiwagi K, Furuno N, Kitamura S et al (2009) Disruption of thyroid hormone function by environmental pollutants. J Health Sci 55:147–160

    Article  CAS  Google Scholar 

  • Li L, Yu B, Zhang X, You T (2015) A novel electrochemiluminescence sensor based on Ru(Bpy)3 2+/N-doped carbon nanodots system for the detection of bisphenol A. Anal Chim Acta 895:104–111

    Article  CAS  Google Scholar 

  • Liu G, Chen Z, Jiang X, Feng DQ, Zhao J, Fan D, Wang W (2016) In-situ hydrothermal synthesis of molecularly imprinted polymers coated carbon dots for fluorescent detection of bisphenol A. Sensors Actuators B Chem 228:302–307

    Article  CAS  Google Scholar 

  • Marchesini GR, Meulenberg E, Haasnoot W, Irth H (2005) Biosensor immunoassays for the detection of bisphenol A. Anal Chim Acta 528:37–45

    Article  CAS  Google Scholar 

  • Moradi R, Sebt SA, Karimi-Maleh H, Sadeghi R, Karimi F, Bahari A (2013) Synthesis and application of FePt/CNTs nanocomposite as a sensor and novel amide ligand as a mediator for simultaneous determination of glutathione, nicotinamide adenine dinucleotide and tryptophan. Phys Chem Chem Phys 15:5888–5897

    Article  CAS  Google Scholar 

  • Najafi M, Khalilzadeh MA, Karimi-Maleh H (2014) A new strategy for determination of bisphenol A in the presence of Sudan I using a ZnO/CNTs/ionic liquid paste electrode in food samples. Food Chem 158:125–131

    Article  CAS  Google Scholar 

  • Pahlavan A, Karimi-Maleh H, Karimi F, Aboukazempour Amiri M, Khoshnama Z, Roodbari Shahmiri M, Keyvanfard M (2014) Application of CdO nanoparticle ionic liquid modified carbon paste electrode as a high sensitive biosensor for square wave voltammetric determination of NADH. Mater Sci Eng C 45:210–215

    Article  CAS  Google Scholar 

  • Palanza P, Gioiosa L, vom Saal FS, Parmigiani S (2008) Effects of developmental exposure to bisphenol A on brain and behavior in mice. Environ Res 108:150–157

    Article  CAS  Google Scholar 

  • Pan D, Gu Y, Lan H, Sun Y, Gao H (2015) Functional graphene-gold nano-composite fabricated electrochemical biosensor for direct and rapid detection of bisphenol A. Anal Chim Acta 853:297–302

    Article  CAS  Google Scholar 

  • Raoof JB, Ojani R, Karimi-Maleh H (2008) Carbon paste electrode incorporating 1-[4-(ferrocenylethynyl) phenyl]-1-ethanone for electrocatalytic and voltammetric determination of tryptophan. Electroanalysis 20:1259–1262

    Article  CAS  Google Scholar 

  • Shahmiri MR, Bahari A, Karimi-Maleh H, Hosseinzadeh R, Mirnia N (2013) Ethynylferrocene–NiO/MWCNT nanocomposite modified carbon paste electrode as a novel voltammetric sensor for simultaneous determination of glutathione and acetaminophen. Sensors Actuators B Chem 177:70–77

    Article  CAS  Google Scholar 

  • Singh S, Li SS (2012) Bisphenol A and phthalates exhibit similar toxicogenomics and health effects. Gene 494:85–91

    Article  CAS  Google Scholar 

  • vom Saal FS, Nagel SC, Coe BL, Angle BM, Taylor JA (2012) The estrogenic endocrine disrupting chemical bisphenol A (BPA) and obesity. Mol Cell Endocrinol 354:74–84

    Article  Google Scholar 

  • Wang Q, Wang Y, Liu S et al (2012) Voltammetric detection of bisphenol a by a chitosan–graphene composite modified carbon ionic liquid electrode. Thin Solid Films 520:4459–4464

    Article  CAS  Google Scholar 

  • Wang JY, Su YL, Wu BH, Cheng SH (2016) Reusable electrochemical sensor for bisphenol A based on ionic liquid functionalized conducting polymer platform. Talanta 147:103–110

    Article  CAS  Google Scholar 

  • Yaghoubian H, Karimi-Maleh H, Khalilzadeh MA, Karimi F (2009) Electrocatalytic oxidation of levodopa at a ferrocene modified carbon nanotube paste electrode. Int J Electrochem Sci 4:993–1003

    Google Scholar 

  • Yu X, Chen Y, Chang L, Zhou L, Tang F, Wu X (2013) β-Cyclodextrin non-covalently modified ionic liquid-based carbon paste electrode as a novel voltammetric sensor for specific detection of bisphenol A. Sensors Actuators B Chem 186:648–656

    Article  CAS  Google Scholar 

  • Yu P, Liu Y, Zhang X et al (2016) A novel electrochemical aptasensor for bisphenol A assay based on triple-signaling strategy. Biosen Bioelectron 79:22–28

    Article  CAS  Google Scholar 

  • Zehani N, Fortgang P, Lachgar MS et al (2015) Highly sensitive electrochemical biosensor for bisphenol A detection based on a diazonium-functionalized boron-doped diamond electrode modified with a multi-walled carbon nanotube-tyrosinase hybrid film. Biosen Bioelectron 74:830–835

    Article  CAS  Google Scholar 

  • Zhang X, Zhua D, Huanga C, Suna Y, Lee Y (2015) Sensitive detection of bisphenol A in complex samples by in-column molecularly imprinted solid-phase extraction coupled with capillary electrophoresis. Microchem J 121:1–5

    Article  CAS  Google Scholar 

  • Zhang D, Yang J, Ye J et al (2016) Colorimetric detection of bisphenol A based on unmodified aptamer and cationic polymer aggregated gold nanoparticles. Anal Biochem 499:51–56

    Article  CAS  Google Scholar 

  • Zincke T (1905) Ueber die Einwirkung von Brom und von Chlor auf Phenole: Substitutionsproducte, Pseudobromide und Pseudochloride. Justus Leibigs Annals Chemie 343:75–99

    Article  CAS  Google Scholar 

Download references

Acknowledgments

The authors gratefully acknowledge the Islamic Azad University, Falavarjan Branch research council for the support of this work.

Author information

Authors and Affiliations

  1. Department of Biochemistry, Falavarjan Branch, Islamic Azad University, Isfahan, Iran

    Masoud Fouladgar

Authors
  1. Masoud Fouladgar
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Masoud Fouladgar.

Ethics declarations

Funding

This work was supported by the Islamic Azad University, Falavarjan Branch research council.

Conflict of Interest

Masoud Fouladgar declares that he has no conflict of interest.

Ethical Approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed Consent

Not applicable.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Fouladgar, M. Nanostructured Sensor for Simultaneous Determination of Trace Amounts of Bisphenol A and Vitamin B6 in Food Samples. Food Anal. Methods 10, 1507–1514 (2017). https://doi.org/10.1007/s12161-016-0683-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12161-016-0683-3

Keywords

Search

Navigation