Food Analytical Methods

, Volume 10, Issue 4, pp 992–998 | Cite as

Determination of Arsenic in Fruit Juices Using Inductively Coupled Plasma Tandem Mass Spectrometry (ICP-MS/MS)

  • Fernanda C. Pinheiro
  • Clarice D. B. Amaral
  • Daniela Schiavo
  • Joaquim A. Nóbrega
Article

Abstract

Reports from the US media have raised the attention towards a possible contamination of apple juices by As. The study here described presents the development of an analytical procedure using inductively coupled plasma tandem mass spectrometry (ICP-MS/MS) for determination of As in apple and orange juices commercialized in the Tetra Pack® package. The microwave-assisted acid digestion of juice was carried out using closed vessels and 2 mol/L HNO3 plus H2O2. These conditions are favorable for a better analytical blank control. Suitable recoveries were reached when promoting reaction with O2 inside the octopole reaction system (ORS3), and the monitoring of 75As16O+ significantly improved the accuracy of the analysis reaching a limit of detection of 0.013 μg/L. Recoveries varied from 88 to 109 % in the MS/MS mass-shift mode. The As concentrations determined in fruit juices ranged from 0.126 to 1.45 μg/L, and they were significantly lower than the maximum tolerable limits imposed by the US and Brazilian legislations. Thus, ICP-MS/MS operated in the reaction mode was an effective instrumental strategy for overcoming spectral interferences, such as 40Ar35Cl+, in As determination as 75As16O+ and allowed the accurate determination of As at trace levels.

Keywords

Arsenic Ultra-traces ICP-MS/MS Octopole reaction cell Mass-shift 

References

  1. Agência Nacional de Vigilância Sanitária (2013) Resolution No. 42—Regulation MERCOSUR August 30, 2013. http://portal.anvisa.gov.br/wps/wcm/connect/8100bb8040eac2e8b590b79cca79f4cf/RDC+n%C2%BA+42_2013_final.pdf?MOD=AJPERES. Accessed 06 Feb 2016
  2. Allain P, Jaunault L, Mauras Y, Mermet J-M, Delaporte T (1991) Signal enhancement of elements due to the presence of carbon containing compounds in inductively coupled plasma mass spectrometry. Anal Chem 63:1497–1498CrossRefGoogle Scholar
  3. Amais RS, Virgilio A, Schiavo D, Nóbrega JA (2015) Tandem mass spectrometry (ICP-MS/MS) for overcoming molybdenum oxide interferences on cadmium determination in milk. Microchem J 120:64–68CrossRefGoogle Scholar
  4. Amaral CDB, Amais RS, Fialho LL, Schiavo D, Amorim T, Nogueira ARA, Rocha FRP, Nóbrega JA (2015a) A novel strategy to determine As, Cr, Hg and V in drinking water by ICP-MS/MS. Anal Methods 7(3):1215–1220CrossRefGoogle Scholar
  5. Amaral CDB, Amais RS, Fialho LL, Schiavo D, Nogueira ARA, Nóbrega JA (2015b) Determination of carbon in digested samples and amino acids by inductively coupled plasma tandem mass spectrometry. Microchem J 122:29–32CrossRefGoogle Scholar
  6. Araújo GCL, Gonzalez MH, Ferreira AG, Nogueira ARA, Nóbrega JA (2002) Effect of acid concentration on closed-vessel microwave-assisted digestion of plant materials. Spectrochim Acta, Part B 57(12):2121–2132CrossRefGoogle Scholar
  7. Assis RA, Küchler IL, Miekeley N, Silveira CLP (2008) Trace elements and sodium in grape juice: nutritional and toxicological aspects. Quim Nov. 31(8):1948–1952Google Scholar
  8. Balcaen L, Woods G, Resanoc M, Vanhaecke F (2013) Accurate determination of S in organic matrices using isotope dilution ICP-MS/MS. J Anal At Spectrom 28:33–39CrossRefGoogle Scholar
  9. Balcaen L, Bolea-Fernandez E, Resano M, Vanhaecke F (2015) Inductively coupled plasma-tandem mass spectrometry (ICP-MS/MS): a powerful and universal tool for the interference-free determination of (ultra)trace elements—a tutorial review. Anal Chim Acta 894(24):7–19CrossRefGoogle Scholar
  10. Barnes KW (1997) Trace metal determinations in fruit, juice and juice products using an axially viewed plasma. At Spectrosc 18(3):84–100Google Scholar
  11. Bizzi CA, Flores EMM, Barin JS, Garcia EE, Nóbrega JA (2011) Understanding the process of microwave-assisted digestion combining diluted nitric acid and oxygen as auxiliary reagent. Microchem J 9(2):193–196CrossRefGoogle Scholar
  12. Bizzi CA, Flores ELM, Nóbrega JA, Oliveira JSS, Schmidt L, Mortari SR (2014) Evaluation of a digestion procedure based on the use of diluted nitric acid solutions and H2O2 for the multielement determination of whole milk powder and bovine liver by ICP-based techniques. J Anal At Spectrom 29(2):332–338CrossRefGoogle Scholar
  13. Bizzi CA, Barin JS, Müllera EI, Schmidt L, Nóbrega JA (2015) Flores ELM (2015) evaluation of oxygen pressurized microwave-assisted digestion of botanical materials using diluted nitric acid. Talanta 83(5):1324–1328CrossRefGoogle Scholar
  14. Bolea-Fernandez E, Balcaen L, Resano M, Vanhaecke F (2015) Interference-free determination of ultra-trace concentrations of arsenic and selenium using methyl fluoride as a reaction gas in ICP–MS/MS. Anal Bioanal Chem 407:919–929CrossRefGoogle Scholar
  15. Diez Fernández S, Sugishama N, Ruiz Encinar J, Sanz-Medel A (2012) Triple quad ICPMS (ICPQQQ) as a new tool for absolute quantitative proteomics and Phosphoproteomics. Anal Chem 84(14):5851–5857CrossRefGoogle Scholar
  16. Flórez MR, García-Ruiz E, Bolea-Fernández E, Vanhaecke F, Resano M (2016) A simple dilute-and-shoot approach for the determination of ultra-trace levels of arsenic in biological fluids via ICP-MS using CH3F/He as a reaction gas. J Anal At Spectrom 31:245–251CrossRefGoogle Scholar
  17. Food and Drug Administration (2008) Hazard assessment and level of concern—apple juice. http://www.fda.gov/Food/FoodborneIllnessContaminants/Metals/ucm277681.htm. Accessed 06 Feb 2016
  18. Food and Drug Administration (2011) Arsenic in apple juice analytical results, 2005–2011 toxic elements food and foodware program. http://www.fda.gov/Food/FoodborneIllnessContaminants/Metals/ucm273328.htm. Accessed 06 Feb 2016
  19. Food and Drug Administration (2013) Questions & answers: apple juice and arsenic. Disponível em: <http://www.fda.gov/Food/FoodborneIllnessContaminants/Metals/ucm271595.htm. Accessed 06 Feb 2016
  20. Gouveia ST, Silva FV, Costa LM, Nogueira ARA, Nóbrega JA (2001) Determination of residual carbon by inductively-coupled plasma optical emission spectrometry with axial and radial view configurations. Anal Chim Acta 445(2):269–275CrossRefGoogle Scholar
  21. International Agency for Research on Cancer (2012) IARC monographs on the evaluation of carcinogenic risks to humans. http://monographs.iarc.fr/ENG/Monographs/vol100C/mono100C.pdf. Accessed 04 April 2016
  22. Jackson BP (2015) Fast ion chromatography-ICP-QQQ for arsenic speciation. J Anal At Spectrom 30:1405–1407CrossRefGoogle Scholar
  23. Jackson BP, Libab A, Nelson J (2015) Advantages of reaction cell ICP-MS on doubly charged interferences for arsenic and selenium analysis in foods. J Anal At Spectrom 30(5):1179–1183CrossRefGoogle Scholar
  24. Magdas DA, Dehelean A, Puscas R (2012) Isotopic and elemental determination in some Romanian apple fruit juices. Scientific World J 2012:1–7CrossRefGoogle Scholar
  25. Maja W, Szymczycha-madeja A (2014) Effect of sample preparation procedure for the determination of As, Sb and Se in fruit juices by HG-ICP-OES. Food Chem 159:414–419CrossRefGoogle Scholar
  26. Martinez VD, Vucic EA, Becker-Santos DD, Gil L, Lam WL (2011) Arsenic exposure and the induction of human cancers. J Toxicol 2011:1–13CrossRefGoogle Scholar
  27. Molin M, Ulven SM, Meltzer HM, Alexander J (2015) Arsenic in the human food chain, biotransformation and toxicology—review focusing on seafood arsenic. J Trace Elem Med Biol 31:249–259CrossRefGoogle Scholar
  28. Pettine M, Casentini B, Mastroianni D, Capri S (2007) Dissolved inorganic carbon effect in the determination of arsenic and chromium in mineral waters by inductively coupled plasma-mass spectrometry. Anal Chim Acta 599(2):191–198CrossRefGoogle Scholar
  29. Pétursdóttir AH, Friedrich N, Musil S, Raab A, Gunnlaugsd’ottir H, Krupp EM, Feldmann J (2014) Hydride generation ICP-MS as a simple method for determination of inorganic arsenic in rice for routine biomonitoring. Anal Methods 6:5392–5396CrossRefGoogle Scholar
  30. Schoof RA, Yost LJ, Eickhoff J, Crecelius EA, Cragin DW, Meacher DM, Menzel DB (1999) A market basket survey of inorganic arsenic in food. Food Chem Toxicol 37(8):839–846CrossRefGoogle Scholar
  31. Thomas RJ (2013) Practical guide to ICP-MS, 3rd edn. CRC Press, Boca Raton, pp. 73–90Google Scholar
  32. Tufuor JK, Bentum JK, Essumang DK, Koranteng-addo JE (2011) Analysis of heavy metals in citrus juice from the Abura-Asebu-Kwamankese district, Ghana. J Chem Pharm Res 3(2):397–402Google Scholar
  33. Virgilio A, Amais RS, Schiavo D, Nóbrega JA (2015) Dilute-and-shoot procedure for determination of As, Cr, P, Pb, Si, and V in ethanol fuel by inductively coupled plasma tandem mass spectrometry. Energy Fuel 29(7):4339–4344CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Fernanda C. Pinheiro
    • 1
  • Clarice D. B. Amaral
    • 1
  • Daniela Schiavo
    • 2
  • Joaquim A. Nóbrega
    • 1
  1. 1.Group for Applied Instrumental Analysis, Department of ChemistryFederal University of São CarlosSão CarlosBrazil
  2. 2.Agilent TechnologiesSão PauloBrazil

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