Food Analytical Methods

, Volume 10, Issue 4, pp 992–998 | Cite as

Determination of Arsenic in Fruit Juices Using Inductively Coupled Plasma Tandem Mass Spectrometry (ICP-MS/MS)

  • Fernanda C. Pinheiro
  • Clarice D. B. Amaral
  • Daniela Schiavo
  • Joaquim A. Nóbrega


Reports from the US media have raised the attention towards a possible contamination of apple juices by As. The study here described presents the development of an analytical procedure using inductively coupled plasma tandem mass spectrometry (ICP-MS/MS) for determination of As in apple and orange juices commercialized in the Tetra Pack® package. The microwave-assisted acid digestion of juice was carried out using closed vessels and 2 mol/L HNO3 plus H2O2. These conditions are favorable for a better analytical blank control. Suitable recoveries were reached when promoting reaction with O2 inside the octopole reaction system (ORS3), and the monitoring of 75As16O+ significantly improved the accuracy of the analysis reaching a limit of detection of 0.013 μg/L. Recoveries varied from 88 to 109 % in the MS/MS mass-shift mode. The As concentrations determined in fruit juices ranged from 0.126 to 1.45 μg/L, and they were significantly lower than the maximum tolerable limits imposed by the US and Brazilian legislations. Thus, ICP-MS/MS operated in the reaction mode was an effective instrumental strategy for overcoming spectral interferences, such as 40Ar35Cl+, in As determination as 75As16O+ and allowed the accurate determination of As at trace levels.


Arsenic Ultra-traces ICP-MS/MS Octopole reaction cell Mass-shift 


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Fernanda C. Pinheiro
    • 1
  • Clarice D. B. Amaral
    • 1
  • Daniela Schiavo
    • 2
  • Joaquim A. Nóbrega
    • 1
  1. 1.Group for Applied Instrumental Analysis, Department of ChemistryFederal University of São CarlosSão CarlosBrazil
  2. 2.Agilent TechnologiesSão PauloBrazil

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