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Annals of Behavioral Medicine

, Volume 51, Issue 1, pp 137–146 | Cite as

Sleep Habits and Susceptibility to Upper Respiratory Illness: the Moderating Role of Subjective Socioeconomic Status

  • Aric A. PratherEmail author
  • Denise Janicki-Deverts
  • Nancy E. Adler
  • Martica Hall
  • Sheldon CohenEmail author
Original Article

Abstract

Background

Sleep is a predictor of infectious illness that may depend on one’s socioeconomic status (SES).

Purpose

This study aimed to investigate the moderating effects of objective and subjective SES on sleep-clinical cold risk link and test whether nasal inflammation serves as a plausible biological pathway.

Methods

This study combined data (n = 732) from three viral challenge studies. Measures of self-reported sleep and objective and subjective measures of SES were obtained. Participants were quarantined and administrated rhinovirus (RV) or influenza virus and monitored over 5 (RV) or 6 (influenza) days for the development of a cold. Symptom severity, including mucus production and nasal clearance time, and levels of nasal cytokines (interleukin (IL)-6 and IL-1β) were measured prior to administration and each day during the quarantined period.

Results

Subjective SES, but not objective SES, moderated associations between shorter sleep duration and increased likelihood of a clinical cold. Compared to ≥8-hour sleepers, ≤6-hour sleepers with low subjective SES were at increased risk for developing a cold (OR = 2.57, 95% CI 1.10–6.02). There was no association between sleep duration and colds in high subjective SES participants. Among infected individuals who reported low subjective SES, shorter sleep duration was associated with greater mucus production. There was no evidence that markers of nasal inflammation mediated the link between sleep duration and cold susceptibility among those reporting low subjective SES.

Conclusion

Subjective SES may reflect an important social factor for understanding vulnerability to and protection against infectious illness among short sleepers.

Keywords

Sleep Upper respiratory infection Socioeconomic status Cytokines 

Notes

Acknowledgments

The data used for this article were collected by the Laboratory for the Study of Stress, Immunity, and Disease at Carnegie Mellon University under the directorship of Sheldon Cohen, PhD and were accessed via the Common Cold Project (CCP) website (www.commoncoldproject.com). CCP data are made publically available through a grant from the National Center for Complementary and Integrative Health (AT006694); the conduct of the studies was supported by grants from the National Institute of Mental Health (MH50429), the National Heart, Lung, and Blood Institute (HL65111; HL65112), and the National Institute for Allergy and Infectious Diseases (AI066367); secondary support was provided by a grant from the National Institutes of Health to the University of Pittsburgh Clinical and Translational Science Institute (UL1 RR024153 and UL1 RT000005), and supplemental support was provided by John D. and Catherine T. MacArthur Foundation Research Network on Socioeconomic Status & Health. Dr. Prather’s participation was supported by a grant from the National Heart, Lung, & Blood Institute (K08HL112961).

Compliance with Ethical Standards

Authors’ Statement of Conflict of Interest and Adherence to Ethical Standards

Dr. Prather is currently a paid consultant for Posit Science. He reports no other potential conflicts of interest. Janicki-Deverts, Adler, Hall, Cohen declare that they have no conflict of interest.

References

  1. 1.
    Luyster FS, Strollo PJ, Jr., Zee PC, et al.: Sleep: A health imperative. Sleep. 2012, 35:727–734.Google Scholar
  2. 2.
    Buysse DJ: Sleep health: Can we define it? Does it matter? Sleep. 2014, 37:9–17.PubMedPubMedCentralGoogle Scholar
  3. 3.
    Cappuccio FP, D'Elia L, Strazzullo P, Miller MA: Quantity and quality of sleep and incidence of type 2 diabetes: A systematic review and meta-analysis. Diabetes Care. 2010, 33:414–420.CrossRefPubMedGoogle Scholar
  4. 4.
    Cappuccio FP, Cooper D, D'Elia L, Strazzullo P, Miller MA: Sleep duration predicts cardiovascular outcomes: A systematic review and meta-analysis of prospective studies. Eur Heart J. 2011, 32:1484–1492.CrossRefPubMedGoogle Scholar
  5. 5.
    Cohen S, Doyle WJ, Alper CM, Janicki-Deverts D, Turner RB: Sleep habits and susceptibility to the common cold. Arch Intern Med. 2009, 169:62–67.CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    Prather AA, Janicki-Deverts D, Hall MH, Cohen S: Behaviorally assessed sleep and susceptibility to the common cold. Sleep. 2015, 38:1353–1359.PubMedPubMedCentralGoogle Scholar
  7. 7.
    Irwin MR: Why sleep is important for health: A psychoneuroimmunology perspective. Annu Rev Psychol. 2015, 66:143–172.CrossRefPubMedGoogle Scholar
  8. 8.
    Besedovsky L, Lange T, Born J: Sleep and immune function. Pflugers Arch. 2012, 463:121–137.CrossRefPubMedGoogle Scholar
  9. 9.
    Bollinger T, Bollinger A, Skrum L, et al.: Sleep-dependent activity of T cells and regulatory T cells. Clin Exp Immunol. 2009, 155:231–238.CrossRefPubMedPubMedCentralGoogle Scholar
  10. 10.
    Dimitrov S, Lange T, Tieken S, Fehm HL, Born J: Sleep associated regulation of T helper 1/T helper 2 cytokine balance in humans. Brain Behav Immun. 2004, 18:341–348.CrossRefPubMedGoogle Scholar
  11. 11.
    Irwin M, McClintick J, Costlow C, et al.: Partial night sleep deprivation reduces natural killer and cellular immune responses in humans. FASEB J. 1996, 10:643–653.PubMedGoogle Scholar
  12. 12.
    Irwin MR, Olmstead R, Carroll JE: Sleep disturbance, sleep duration, and inflammation: A systematic review and meta-analysis of cohort studies and experimental sleep deprivation. Biol Psychiatry. 2016, 18:40–52.CrossRefGoogle Scholar
  13. 13.
    Seeman T, Epel E, Gruenewald T, Karlamangla A, McEwen BS: Socio-economic differentials in peripheral biology: Cumulative allostatic load. Ann N Y Acad Sci. 2010, 1186:223–239.CrossRefPubMedGoogle Scholar
  14. 14.
    Chen E, Miller GE: Socioeconomic status and health: Mediating and moderating factors. Annu Rev Clin Psychol. 2013, 9:723–749.CrossRefPubMedGoogle Scholar
  15. 15.
    Petersen KL, Marsland AL, Flory J, et al.: Community socioeconomic status is associated with circulating interleukin-6 and C-reactive protein. Psychosom Med. 2008, 70:646–652.CrossRefPubMedGoogle Scholar
  16. 16.
    Steptoe A, Kunz-Ebrecht S, Owen N, et al.: Socioeconomic status and stress-related biological responses over the working day. Psychosom Med. 2003, 65:461–470.CrossRefPubMedGoogle Scholar
  17. 17.
    Pollitt RA, Kaufman JS, Rose KM, et al.: Cumulative life course and adult socioeconomic status and markers of inflammation in adulthood. J Epidemiol Community Health. 2008, 62:484–491.CrossRefPubMedGoogle Scholar
  18. 18.
    Friedman EM, Herd P: Income, education, and inflammation: Differential associations in a national probability sample (the MIDUS study). Psychosom Med. 2010, 72:290–300.CrossRefPubMedPubMedCentralGoogle Scholar
  19. 19.
    Koster FT, McGregor DD, Mackaness GB: The mediator of cellular immunity. II. Migration of immunologically committed lymphocytes into inflammatory exudates. J Exp Med. 1971, 133:400–409.CrossRefPubMedPubMedCentralGoogle Scholar
  20. 20.
    Fagundes CP, Bennett JM, Alfano CM, et al.: Social support and socioeconomic status interact to predict Epstein-Barr virus latency in women awaiting diagnosis or newly diagnosed with breast cancer. Health Psychol. 2012, 31:11–19.CrossRefPubMedGoogle Scholar
  21. 21.
    Janicki-Deverts D, Cohen S, Doyle WJ, Marsland AL, Bosch J: Childhood environments and cytomegalovirus serostatus and reactivation in adults. Brain Behav Immun. 2014, 40:174–181.CrossRefPubMedPubMedCentralGoogle Scholar
  22. 22.
    Minkel JD, Banks S, Htaik O, et al.: Sleep deprivation and stressors: Evidence for elevated negative affect in response to mild stressors when sleep deprived. Emotion. 2012, 12:1015–1020.CrossRefPubMedPubMedCentralGoogle Scholar
  23. 23.
    Yoo SS, Gujar N, Hu P, Jolesz FA, Walker MP: The human emotional brain without sleep—a prefrontal amygdala disconnect. Curr Biol. 2007, 17:R877–878.CrossRefPubMedGoogle Scholar
  24. 24.
    Franzen PL, Gianaros PJ, Marsland AL, et al.: Cardiovascular reactivity to acute psychological stress following sleep deprivation. Psychosom Med. 2011, 73:679–682.CrossRefPubMedPubMedCentralGoogle Scholar
  25. 25.
    Bailis DS, Segall A, Mahon MJ, Chipperfield JG, Dunn EM: Perceived control in relation to socioeconomic and behavioral resources for health. Soc Sci Med. 2001, 52:1661–1676.CrossRefPubMedGoogle Scholar
  26. 26.
    Adler N, Snibe AC: The role of psychosocial processes in explaining the gradient between socioeconomic status and health. Curr Dir in Psychol Sci. 2003, 12:119–123.CrossRefGoogle Scholar
  27. 27.
    Miller G, Chen E, Cole SW: Health psychology: Developing biologically plausible models linking the social world and physical health. Annu Rev Psychol. 2009, 60:501–524.CrossRefPubMedGoogle Scholar
  28. 28.
    Adler NE, Boyce T, Chesney MA, et al.: Socioeconomic status and health. The challenge of the gradient. Am Psychol. 1994, 49:15–24.CrossRefPubMedGoogle Scholar
  29. 29.
    Adler N, Singh-Manoux A, Schwartz J, et al.: Social status and health: A comparison of British civil servants in Whitehall-II with European- and African-Americans in CARDIA. Soc Sci Med. 2008, 66:1034–1045.CrossRefPubMedGoogle Scholar
  30. 30.
    Adler NE, Epel ES, Castellazzo G, Ickovics JR: Relationship of subjective and objective social status with psychological and physiological functioning: Preliminary data in healthy white women. Health Psychol. 2000, 19:586–592.CrossRefPubMedGoogle Scholar
  31. 31.
    Cohen S, Alper CM, Doyle WJ, et al.: Objective and subjective socioeconomic status and susceptibility to the common cold. Health Psychol. 2008, 27:268–274.CrossRefPubMedGoogle Scholar
  32. 32.
    Cohen S, Doyle WJ, Skoner DP: Psychological stress, cytokine production, and severity of upper respiratory illness. Psychosom Med. 1999, 61:175–180.CrossRefPubMedGoogle Scholar
  33. 33.
    Doyle WJ, Gentile DA, Cohen S: Emotional style, nasal cytokines, and illness expression after experimental rhinovirus exposure. Brain Behav Immun. 2006, 20:175–181.CrossRefPubMedGoogle Scholar
  34. 34.
    Gwaltney JM, Jr, Colonno RJ, Hamparian VV, Turner RB: Rhinovirus. In N. J. Schmidt and R. W. Emmons (eds), Diagnostic procedures for viral, rickettsial and chlamydial infections. Washington, D.C.: American Public Health Association, 1989, 579–614.Google Scholar
  35. 35.
    Buysse DJ, Reynolds CF, 3rd, Monk TH, Berman SR, Kupfer DJ: The Pittsburgh Sleep Quality Index: A new instrument for psychiatric practice and research. Psychiatry Res. 1989, 28:193–213.CrossRefPubMedGoogle Scholar
  36. 36.
    Cohen S, Kamarck T, Mermelstein R: A global measure of perceived stress. J Health Soc Behav. 1983, 24:385–396.CrossRefPubMedGoogle Scholar
  37. 37.
    Goldberg LR: The development of markers for the big-five factor structure. Psychol Assess. 1992:26–42.Google Scholar
  38. 38.
    Goldberg LR: The intenational personality item pool and the future of public-domain personality measures. J Res Pers. 2006, 40:84–96.CrossRefGoogle Scholar
  39. 39.
    Gwaltney JM, Jr, Colonno RI, Hamparian VV, Turner RB: Rhinovirus. In N. I. Schmidt and R. W. Ernmons (eds), Diagnostic procedures for viral, rickettsial, and chlamydial infections. Washington, DC: American Public Healh Association, 1989, 579–614.Google Scholar
  40. 40.
    Doyle WJ, McBride TP, Skoner DP, et al.: A double-blind, placebo-controlled clinical trial of the effect of chlorpheniramine on the response of the nasal airway, middle ear and eustachian tube to provocative rhinovirus challenge. Pediatr Infect Dis J. 1988, 7:229–238.CrossRefPubMedGoogle Scholar
  41. 41.
    Cohen S, Doyle WJ, Skoner DP, Rabin BS, Gwaltney JM, Jr: Social ties and susceptibility to the common cold. JAMA. 1997, 277:1940–1944.CrossRefPubMedGoogle Scholar
  42. 42.
    Baum A, Garofalo JP, Yali AM: Socioeconomic status and chronic stress. Does stress account for SES effects on health? Ann N Y Acad Sci. 1999, 896:131–144.CrossRefPubMedGoogle Scholar
  43. 43.
    McEwen BS, Gianaros PJ: Central role of the brain in stress and adaptation: Links to socioeconomic status, health, and disease. Ann N Y Acad Sci. 2010, 1186:190–222.CrossRefPubMedPubMedCentralGoogle Scholar
  44. 44.
    Segerstrom SC, Miller GE: Psychological stress and the human immune system: A meta-analytic study of 30 years of inquiry. Psychol Bull. 2004, 130:601–630.CrossRefPubMedPubMedCentralGoogle Scholar
  45. 45.
    Gruenewald TL, Cohen S, Matthews KA, Tracy R, Seeman TE: Association of socioeconomic status with inflammation markers in black and white men and women in the coronary artery risk development in young adults (CARDIA) study. Soc Sci Med. 2009, 69:451–459.CrossRefPubMedPubMedCentralGoogle Scholar
  46. 46.
    Ranjit N, Diez-Roux AV, Shea S, et al.: Socioeconomic position, race/ethnicity, and inflammation in the multi-ethnic study of atherosclerosis. Circulation. 2007, 116:2383–2390.CrossRefPubMedGoogle Scholar
  47. 47.
    Gallo LC, Matthews KA: Understanding the association between socioeconomic status and physical health: Do negative emotions play a role? Psychol Bull. 2003, 129:10–51.CrossRefPubMedGoogle Scholar
  48. 48.
    Kraus MW, Piff PK, Keltner D: Social class, sense of control, and social explanation. J Pers Soc Psychol. 2009, 97:992–1004.CrossRefPubMedGoogle Scholar
  49. 49.
    Prather AA, Epel ES, Cohen BE, Neylan TC, Whooley MA: Gender differences in the prospective associations of self-reported sleep quality with biomarkers of systemic inflammation and coagulation: Findings from the heart and soul study. J Psychiatr Res. 2013, 47:1228–1235.CrossRefPubMedGoogle Scholar
  50. 50.
    Patel SR, Zhu X, Storfer-Isser A, et al.: Sleep duration and biomarkers of inflammation. Sleep. 2009, 32:200–204.PubMedPubMedCentralGoogle Scholar
  51. 51.
    Murphy SL, Xu J, Kochanek KD: Deaths: Final data for 2010. Natl Vital Stat Rep. 2013, 61:1–117.PubMedGoogle Scholar
  52. 52.
    Irwin MR, Olmstead R, Carrillo C, et al.: Cognitive behavioral therapy vs. tai chi for late life insomnia and inflammatory risk: A randomized controlled comparative efficacy trial. Sleep. 2014, 37:15431552.PubMedPubMedCentralGoogle Scholar
  53. 53.
    Black DS, O'Reilly GA, Olmstead R, Breen EC, Irwin MR: Mindfulness meditation and improvement in sleep quality and daytime impairment among older adults with sleep disturbances: A randomized clinical trial. JAMA Intern Med. 2015, 175:494–501.CrossRefPubMedPubMedCentralGoogle Scholar
  54. 54.
    Hotez PJ: Neglected infections of poverty in the United States of America. PLoS Negl Trop Dis. 2008, 2:e256.CrossRefPubMedPubMedCentralGoogle Scholar
  55. 55.
    Bate SL, Dollard SC, Cannon MJ: Cytomegalovirus seroprevalence in the United States: The national health and nutrition examination surveys, 1988-2004. Clin Infect Dis. 2010, 50:1439–1447.CrossRefPubMedGoogle Scholar
  56. 56.
    Capturing social and behavioral domains and measures in electronic health records: Phase 2. Washington, D.C.: National Academies Press; 2014.Google Scholar

Copyright information

© The Society of Behavioral Medicine 2016

Authors and Affiliations

  1. 1.Department of PsychiatryUniversity of CaliforniaSan FranciscoUSA
  2. 2.Center for Health and CommunityUniversity of CaliforniaSan FranciscoUSA
  3. 3.Department of PsychiatryUniversity of Pittsburgh Medical CenterPittsburghUSA
  4. 4.Department of PsychologyCarnegie Mellon UniversityPittsburghUSA

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