Skip to main content
SpringerLink
Log in

Leptin, Somatic Depressive Symptoms and the Metabolic Syndrome: a Comment on Chirinos et al.

  • Invited Commentary
  • Published:
Annals of Behavioral Medicine

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Katon WJ. Epidemiology and treatment of depression in patients with chronic medical illness. Dialogues Clin Neurosci. 2011; 13: 7-23.

    PubMed  Google Scholar 

  2. Pasco JA, Jacka FN, Williams LJ, et al. Leptin in depressed women: Cross-sectional and longitudinal data from an epidemiologic study. J Affect Disord. 2008; 107: 221-225.

    Article  PubMed  CAS  Google Scholar 

  3. Labad J, Price JF, Strachan MW, et al. Leptin levels and depressive symptoms in people with type 2 diabetes: The edinburgh type 2 diabetes study. Psychosom Med. 2012; 74: 39-45.

    Article  PubMed  CAS  Google Scholar 

  4. Chirinos DA, Goldberg R, Gellman M, et al. Leptin and its association with somatic depressive symptoms in patients with the metabolic syndrome. Ann Behav Med. 2013. doi:10.1007/s12160-013-9479-5.

  5. Duivis HE, Vogelzangs N, Kupper N, de Jonge P, Penninx BW. Differential association of somatic and cognitive symptoms of depression and anxiety with inflammation: Findings from the Netherlands Study of Depression and Anxiety (NESDA). Psychoneuroendocrinology. 2013. doi:10.1016/j.psyneuen.2013.01.002.

  6. Hafner S, Zierer A, Emeny RT, et al. Social isolation and depressed mood are associated with elevated serum leptin levels in men but not in women. Psychoneuroendocrinology. 2011; 36: 200-209.

    Article  PubMed  CAS  Google Scholar 

  7. Labad J, Price JF, Strachan MW, et al. Serum leptin and cognitive function in people with type 2 diabetes. Neurobiol Aging. 2012; 33: 2938-2941. e2932.

    Article  PubMed  Google Scholar 

  8. Clegg DJ, Riedy CA, Smith KA, Benoit SC, Woods SC. Differential sensitivity to central leptin and insulin in male and female rats. Diabetes. 2003; 52: 682-687.

    Article  PubMed  CAS  Google Scholar 

  9. Van Cauter E, Spiegel K, Tasali E, Leproult R. Metabolic consequences of sleep and sleep loss. Sleep Med. 2008; 9(Suppl 1): S23-S28.

    Article  PubMed  Google Scholar 

  10. Pillar G, Shehadeh N. Abdominal fat and sleep apnea: The chicken or the egg? Diabetes Care. 2008; 31(Suppl 2): S303-S309.

    Article  PubMed  Google Scholar 

  11. Campo A, Fruhbeck G, Zulueta JJ, et al. Hyperleptinaemia, respiratory drive and hypercapnic response in obese patients. Eur Respir J. 2007; 30: 223-231.

    Article  PubMed  CAS  Google Scholar 

  12. Gonnissen HK, Hulshof T, Westerterp-Plantenga MS. Chronobiology, endocrinology, and energy- and food-reward homeostasis. Obes Rev. 2013. doi:10.1111/obr.12019.

  13. McClung CA. Circadian genes, rhythms and the biology of mood disorders. Pharmacol Ther. 2007; 114: 222-232.

    Article  PubMed  CAS  Google Scholar 

  14. Garaulet M, Ordovas JM, Madrid JA. The chronobiology, etiology and pathophysiology of obesity. Int J Obes (Lond). 2010; 34: 1667-1683.

    Article  CAS  Google Scholar 

  15. Soria V, Martinez-Amoros E, Escaramis G, et al. Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder. Neuropsychopharmacology. 2010; 35: 1279-1289.

    Article  PubMed  CAS  Google Scholar 

  16. Milagro FI, Gomez-Abellan P, Campion J, et al. CLOCK, PER2 and BMAL1 DNA methylation: Association with obesity and metabolic syndrome characteristics and monounsaturated fat intake. Chronobiol Int. 2012; 29: 1180-1194.

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

Javier Labad has received an Intensification of Research Activity grant (Programme I3SNS-INT11/323) from the Instituto de Salud Carlos III (Spain) during 2012 and 2013.

Conflict of Interest

The authors have no conflict of interest to disclose.

Author information

Authors and Affiliations

  1. Hospital Universitari Institut Pere Mata, IISPV, Universitat Rovira i Virgili. CIBERSAM, Ctra. de l’Institut Pere Mata, s/n, 43206, Reus, Spain

    Javier Labad M.D., Ph.D.

  2. Endocrinology Unit, University/BHF Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, UK

    Rebecca M. Reynolds Ph.D.

Authors
  1. Javier Labad M.D., Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rebecca M. Reynolds Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Javier Labad M.D., Ph.D. or Rebecca M. Reynolds Ph.D..

About this article

Cite this article

Labad, J., Reynolds, R.M. Leptin, Somatic Depressive Symptoms and the Metabolic Syndrome: a Comment on Chirinos et al.. ann. behav. med. 46, 5–6 (2013). https://doi.org/10.1007/s12160-013-9493-7

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12160-013-9493-7

Keywords

Search

Navigation