Does Exposure to Stressors Predict Changes in Physiological Dysregulation?
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The allostatic load framework implies that cumulative exposure to stressors results in multi-system physiological dysregulation.
The purpose of this study was to investigate the effect of stress burden on subsequent changes (2000–2006) in physiological dysregulation.
Data came from a population-based cohort study in Taiwan (n = 521, aged 54+ in 2000, re-examined in 2006). Measures of stressful events and chronic strain were based on questions asked in 1996, 1999, and 2000. A measure of trauma was based on exposure to the 1999 earthquake. Dysregulation was based on 17 biomarkers (e.g., metabolic, inflammatory, neuroendocrine).
There were some small effects among men: chronic strain was associated with subsequent increases in dysregulation (standardized β = 0.08, 95 % CI = 0.01 to 0.20), particularly inflammation; life events were also associated with increased inflammation (β = 0.10, CI = 0.01 to 0.26). There were no significant effects in women.
We found weak evidence that stress burden is associated with changes in dysregulation.
KeywordsStressors Psychological stress Life challenges Allostatic load Physiological dysregulation Biological markers
- 7.Gustafsson PE, Janlert U, Theorell T, Westerlund H, Hammarstrom A. Social and material adversity from adolescence to adulthood and allostatic load in middle-aged women and men: Results from the Northern Swedish Cohort. Ann Behav Med. 2011. doi:10.1007/s12160-011-9309-6.
- 16.Chang M, Lin H, Chuang Y, et al. Social Environment and Biomarkers of Aging Study (SEBAS) in Taiwan, 2000 and 2006: Main documentation for SEBAS longitudinal public use data (released 2012). Ann Arbor, MI: Inter-university Consortium for Political and Social Research [distributor]; 2012; No. ICPSR03792-v5.Google Scholar
- 17.Chang M, Glei D, Goldman N, Weinstein M. The Taiwan biomarker project. In: Weinstein M, Vaupel JW, Wachter KW, eds. Biosocial Surveys. Committee on Advances in Collecting and Utilizing Biological Indicators and Genetic Information in Social Science Surveys, Committee on Population, Division of Behavioral and Social Sciences and Education. Washington, DC: The National Academies Press; 2007: 3-1–3-16.Google Scholar