Abstract
Background
Both depression and smoking have been independently associated with lower heart rate variability (HRV), suggesting dysregulation of cardiac autonomic function. However, no studies have systematically explored the effects of smoking on HRV among depressed patients.
Purpose
This study examined differences in HRV based on smoking status among depressed individuals.
Methods
Electrophysiological data were examined among 77 adult outpatients without a history of myocardial infarction, who met criteria for major depressive disorder or dysthymia. Frequency domain [low frequency (LF), high frequency (HF), LF/HF ratio, respiratory sinus arrhythmia (RSA)] parameters of HRV, and heart rate and inter-beat interval (IBI) data were compared between depressed smokers (n = 34) and depressed nonsmokers (n = 44).
Results
After controlling for covariates, depressed smokers, compared to depressed nonsmokers, displayed significantly lower LF, HF, and RSA.
Conclusions
Among depressed patients, smoking is associated with significantly lower HRV, indicating dysregulated autonomic modulation of the heart.
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Author Note
Christopher B. Harte, Research Service, VA Boston Healthcare System and Department of Psychiatry, Boston University School of Medicine; Gabrielle I. Liverant, Mental Health Service, VA Boston Healthcare System and Department of Psychiatry, Boston University School of Medicine; Denise M. Sloan, National Center for PTSD, Behavioral Science Division, VA Boston Healthcare System, and Department of Psychiatry, Boston University School of Medicine; Barbara W. Kamholz, Mental Health Service, VA Boston Healthcare System, Department of Psychiatry, Boston University School of Medicine, and Department of Psychology, Boston University; Laina Rosebrock, Massachusetts Veterans Epidemiological Research and Information Center, VA Boston Healthcare System; Maurizio Fava, Department of Psychiatry, Massachusetts General Hospital and Department of Psychiatry, Harvard Medical School; Gary B. Kaplan, Mental Health Service, VA Boston Healthcare System and Department of Psychiatry, Pharmacology, and Psychology, Boston University School of Medicine.
This investigation was supported by a VA Career Development Award, Department of Veterans Affairs, awarded to the second author, Dr. Gabrielle Liverant. The authors would like to acknowledge Kimberly Arditte and Daniel Lee for their assistance with recruitment and data collection for this study.
Conflict of Interest Statement
Maurizio Fava has the following lifetime disclosures:
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All other authors have no conflict of interest to disclose.
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Harte, C.B., Liverant, G.I., Sloan, D.M. et al. Association Between Smoking and Heart Rate Variability Among Individuals with Depression. ann. behav. med. 46, 73–80 (2013). https://doi.org/10.1007/s12160-013-9476-8
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DOI: https://doi.org/10.1007/s12160-013-9476-8