Annals of Behavioral Medicine

, Volume 40, Issue 3, pp 325–342

Review and Meta-analysis of Couple-Oriented Interventions for Chronic Illness

  • Lynn M. Martire
  • Richard Schulz
  • Vicki S. Helgeson
  • Brent J. Small
  • Ester M. Saghafi
Original Article

DOI: 10.1007/s12160-010-9216-2

Cite this article as:
Martire, L.M., Schulz, R., Helgeson, V.S. et al. ann. behav. med. (2010) 40: 325. doi:10.1007/s12160-010-9216-2



Evidence continues to build for the impact of the marital relationship on health as well as the negative impact of illness on the partner. Targeting both patient and partner may enhance the efficacy of psychosocial or behavioral interventions for chronic illness.


The purpose of this report is to present a cross-disease review of the characteristics and findings of studies evaluating couple-oriented interventions for chronic physical illness.


We conducted a qualitative review of 33 studies and meta-analyses for a subset of 25 studies.


Identified studies focused on cancer, arthritis, cardiovascular disease, chronic pain, HIV, and Type 2 diabetes. Couple interventions had significant effects on patient depressive symptoms (d = 0.18, p < 0.01, k = 20), marital functioning (d = 0.17, p < 0.01, k = 18), and pain (d = 0.19, p < 0.01, k = 14) and were more efficacious than either patient psychosocial intervention or usual care.


Couple-oriented interventions have small effects that may be strengthened by targeting partners’ influence on patient health behaviors and focusing on couples with high illness-related conflict, low partner support, or low overall marital quality. Directions for future research include assessment of outcomes for both patient and partner, comparison of couple interventions to evidence-based patient interventions, and evaluation of mechanisms of change.


Couples Chronic illness Intervention Meta-analysis 

Copyright information

© The Society of Behavioral Medicine 2010

Authors and Affiliations

  • Lynn M. Martire
    • 1
  • Richard Schulz
    • 2
  • Vicki S. Helgeson
    • 3
  • Brent J. Small
    • 4
  • Ester M. Saghafi
    • 5
  1. 1.Department of Human Development and Family StudiesThe Pennsylvania State UniversityUniversity ParkUSA
  2. 2.Department of Psychiatry and University Center for Social and Urban ResearchUniversity of PittsburghPittsburghUSA
  3. 3.Department of PsychologyCarnegie Mellon UniversityPittsburghUSA
  4. 4.School of Aging StudiesUniversity of South FloridaTampaUSA
  5. 5.Health Sciences Library SystemUniversity of PittsburghPittsburghUSA

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